node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dfrA | fmt | BL1666 | BL1789 | DfrA; COG family: dihydrofolate reductase; PFAM_ID: DiHfolate_red; Belongs to the dihydrofolate reductase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.929 |
dfrA | folC | BL1666 | BL1353 | DfrA; COG family: dihydrofolate reductase; PFAM_ID: DiHfolate_red; Belongs to the dihydrofolate reductase family. | FolC or FpgS; COG family: folylpolyglutamate synthase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase_C. | 0.956 |
dfrA | gcvH | BL1666 | BL1221 | DfrA; COG family: dihydrofolate reductase; PFAM_ID: DiHfolate_red; Belongs to the dihydrofolate reductase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.556 |
dfrA | glyA | BL1666 | BL1035 | DfrA; COG family: dihydrofolate reductase; PFAM_ID: DiHfolate_red; Belongs to the dihydrofolate reductase family. | GlyA; COG family: glycine hydroxymethyltransferase; PFAM_ID: SHMT; PFAM_ID: SHMT. | 0.923 |
dfrA | thyA | BL1666 | BL1665 | DfrA; COG family: dihydrofolate reductase; PFAM_ID: DiHfolate_red; Belongs to the dihydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
dut | nrdE | BL1438 | BL0670 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | NrdE; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.619 |
dut | thyA | BL1438 | BL1665 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.963 |
dut | tmk | BL1438 | BL0484 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.930 |
fmt | dfrA | BL1789 | BL1666 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | DfrA; COG family: dihydrofolate reductase; PFAM_ID: DiHfolate_red; Belongs to the dihydrofolate reductase family. | 0.929 |
fmt | folC | BL1789 | BL1353 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | FolC or FpgS; COG family: folylpolyglutamate synthase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase_C. | 0.617 |
fmt | folD | BL1789 | BL0993 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Bifunctional methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.953 |
fmt | gcvH | BL1789 | BL1221 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.542 |
fmt | glyA | BL1789 | BL1035 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | GlyA; COG family: glycine hydroxymethyltransferase; PFAM_ID: SHMT; PFAM_ID: SHMT. | 0.981 |
fmt | thyA | BL1789 | BL1665 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.792 |
folC | dfrA | BL1353 | BL1666 | FolC or FpgS; COG family: folylpolyglutamate synthase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase_C. | DfrA; COG family: dihydrofolate reductase; PFAM_ID: DiHfolate_red; Belongs to the dihydrofolate reductase family. | 0.956 |
folC | fmt | BL1353 | BL1789 | FolC or FpgS; COG family: folylpolyglutamate synthase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase_C. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.617 |
folC | folD | BL1353 | BL0993 | FolC or FpgS; COG family: folylpolyglutamate synthase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase_C. | Bifunctional methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.440 |
folC | gcvH | BL1353 | BL1221 | FolC or FpgS; COG family: folylpolyglutamate synthase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase_C. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.433 |
folC | glyA | BL1353 | BL1035 | FolC or FpgS; COG family: folylpolyglutamate synthase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase_C. | GlyA; COG family: glycine hydroxymethyltransferase; PFAM_ID: SHMT; PFAM_ID: SHMT. | 0.657 |
folC | metF | BL1353 | BL0797 | FolC or FpgS; COG family: folylpolyglutamate synthase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase; PFAM_ID: Mur_ligase_C. | MetF; COG family: 5,10-methylenetetrahydrofolate reductase; PFAM_ID: MTHFR; Belongs to the methylenetetrahydrofolate reductase family. | 0.629 |