STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (545 aa)    
Predicted Functional Partners:
guaA
GMP synthase glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP.
 
 0.999
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.987
purH
PurH; IMP synthetase; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in aful); PFAM_ID: MGS; PFAM_ID: AICARFT_IMPCHas.
  
 
 0.970
hprT
HgpRT; HprT; COG family: hypoxanthine-guanine phosphoribosyltransferase; PFAM_ID: Pribosyltran; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
 0.962
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
  
 
 0.943
BL1500
GMP reductase; COG family: IMP dehydrogenase/GMP reductase; PFAM_ID: IMPDH_N; PFAM_ID: IMPDH_C.
  
 
0.932
BL0285
Widely conserved hypothetical protein in Ham1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 0.930
pheT
phenylalanine--tRNA ligase beta chain; PheRS; PheT; COG family: emap domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.928
purL
PurL.
  
  
 0.923
BL0851
Conserved hypothetical protein similar to MazG; COG family: predicted pyrophosphatase.
     
  0.900
Your Current Organism:
Bifidobacterium longum
NCBI taxonomy Id: 206672
Other names: B. longum NCC2705, Bifidobacterium longum NCC2705, Bifidobacterium longum str. NCC2705
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.