STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
hemLGlutamate-1-semialdehyde-2,1-aminomutase; TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; KEGG: dvl:Dvul_0218 glutamate-1-semialdehyde aminotransferase; PFAM: Aminotransferase class-III. (422 aa)    
Predicted Functional Partners:
Dde_2576
Porphobilinogen synthase; KEGG: dvu:DVU0856 delta-aminolevulinic acid dehydratase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; Belongs to the ALAD family.
 
 
 0.994
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.990
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.943
Dde_1609
Amino acid adenylation domain protein; SMART: Polyketide synthase, beta-ketoacyl synthase region; TIGRFAM: Amino acid adenylation; KEGG: dae:Dtox_2675 amino acid adenylation domain-containing protein; PFAM: AMP-dependent synthetase/ligase; Beta-ketoacyl synthase, C-terminal; Condensation domain; Beta-ketoacyl synthase, N-terminal; Phosphopantetheine-binding; Acyl transferase; Non-ribosomal peptide synthetase.
  
 
 0.903
Dde_2837
TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; KEGG: dvl:Dvul_2236 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase.
 
  
 0.897
Dde_3181
precorrin-3B C17-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobJ/CibH, precorrin-3B C17-methyltransferase, core; KEGG: cag:Cagg_1264 precorrin-3B C17-methyltransferase; PFAM: Cobalamin (vitamin B12) biosynthesis CbiG, core; Tetrapyrrole methylase.
     
 0.837
Dde_2023
TIGRFAM: Sirohaem synthase, N-terminal; KEGG: dvm:DvMF_0298 siroheme synthase.
   
 0.749
Dde_3179
Putative heme biosynthesis protein; SMART: Transcription regulator, AsnC-type; KEGG: dvm:DvMF_2503 putative transcriptional regulator, AsnC family.
     
 0.679
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.616
Dde_2434
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.587
Your Current Organism:
Desulfovibrio alaskensis
NCBI taxonomy Id: 207559
Other names: D. alaskensis G20, Desulfovibrio alaskensis G20, Desulfovibrio alaskensis str. G20, Desulfovibrio alaskensis strain G20, Desulfovibrio desulfuricans subsp. desulfuricans str. G20
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