STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pobAP-hydroxybenzoate hydroxylase; Catalyzes the incorporation of an atom of dioxygen into p- hydroxybenzoate (p-OHB) to form 3,4-dihydroxybenzoate (3,4DOHB). The reaction occurs in two parts: reduction of the flavin adenine dinucleotide (FAD) in the enzyme by reduced nicotinamide adenine dinucleotide phosphate (NADPH) in response to binding p-hydroxybenzoate to the enzyme and oxidation of reduced FAD with oxygen to form a hydroperoxide, which then oxygenates p-hydroxybenzoate. Belongs to the aromatic-ring hydroxylase family. (394 aa)    
Predicted Functional Partners:
pcaH
Protocatechuate 3,4-dioxygenase, beta subunit; Product name confidence: Class 2 (High similarity to functionally studied protein).
 
  
 0.995
pcaG
Protocatechuate 3,4-dioxygenase, alpha subunit; Product name confidence: Class 2 (High similarity to functionally studied protein).
 
  
 0.993
PA0968
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
     
  0.900
catA
Catechol 1,2-dioxygenase; Product name confidence: Class 2 (High similarity to functionally studied protein).
 
  
 0.887
quiC1
Hypothetical protein; Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways. Is required for growth on either quinate or shikimate as a sole carbon source.
 
  
 0.856
PA0248
Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
   
 0.855
vanA
Vanillate O-demethylase oxygenase subunit; Product name confidence: Class 2 (High similarity to functionally studied protein).
  
  
 0.833
pcaC
Gamma-carboxymuconolactone decarboxylase; Product name confidence: Class 2 (High similarity to functionally studied protein).
 
  
 0.824
vanB
Vanillate O-demethylase oxidoreductase; Product name confidence: Class 2 (High similarity to functionally studied protein).
  
   
 0.808
hpaC
4-hydroxyphenylacetate 3-monooxygenase small chain; Reductase component of the 4-hydroxyphenylacetate (HPA) 3- hydroxylase. Catalyzes the reduction of FAD by NADH. The reduced flavin is then transferred to the oxygenase component HpaB. Is also able to reduce FMN and riboflavin, but preferentially binds FAD. Has no activity with NADPH as the reductant; Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily.
  
  
 0.805
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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