node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA2018 | PA4144 | PA2018 | PA4144 | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter; Product name confidence: Class 2 (High similarity to functionally studied protein). | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | 0.867 |
PA2018 | PA4375 | PA2018 | PA4375 | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter; Product name confidence: Class 2 (High similarity to functionally studied protein). | Probable Resistance-Nodulation-Cell Division (RND) efflux transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.917 |
PA2018 | mexA | PA2018 | PA0425 | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter; Product name confidence: Class 2 (High similarity to functionally studied protein). | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.975 |
PA2018 | mexB | PA2018 | PA0426 | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter; Product name confidence: Class 2 (High similarity to functionally studied protein). | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.904 |
PA2018 | oprJ | PA2018 | PA4597 | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter; Product name confidence: Class 2 (High similarity to functionally studied protein). | Multidrug efflux outer membrane protein OprJ precursor; Channel-forming component of a multidrug resistance efflux pump; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | 0.761 |
PA2018 | oprM | PA2018 | PA0427 | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter; Product name confidence: Class 2 (High similarity to functionally studied protein). | Major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor; The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane co [...] | 0.971 |
PA2018 | oprN | PA2018 | PA2495 | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter; Product name confidence: Class 2 (High similarity to functionally studied protein). | Multidrug efflux outer membrane protein OprN precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.701 |
PA4144 | PA2018 | PA4144 | PA2018 | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.867 |
PA4144 | PA4375 | PA4144 | PA4375 | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | Probable Resistance-Nodulation-Cell Division (RND) efflux transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.920 |
PA4144 | mexA | PA4144 | PA0425 | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.941 |
PA4144 | mexB | PA4144 | PA0426 | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.932 |
PA4144 | oprM | PA4144 | PA0427 | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | Major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor; The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane co [...] | 0.910 |
PA4144 | pvdT | PA4144 | PA2390 | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | PvdT; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.607 |
PA4375 | PA2018 | PA4375 | PA2018 | Probable Resistance-Nodulation-Cell Division (RND) efflux transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.917 |
PA4375 | PA4144 | PA4375 | PA4144 | Probable Resistance-Nodulation-Cell Division (RND) efflux transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | 0.920 |
PA4375 | mexA | PA4375 | PA0425 | Probable Resistance-Nodulation-Cell Division (RND) efflux transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.964 |
PA4375 | mexB | PA4375 | PA0426 | Probable Resistance-Nodulation-Cell Division (RND) efflux transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.915 |
PA4375 | oprM | PA4375 | PA0427 | Probable Resistance-Nodulation-Cell Division (RND) efflux transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor; The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane co [...] | 0.886 |
PA4375 | oprN | PA4375 | PA2495 | Probable Resistance-Nodulation-Cell Division (RND) efflux transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Multidrug efflux outer membrane protein OprN precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.431 |
mexA | PA2018 | PA0425 | PA2018 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.975 |