node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA2019 | PA4144 | PA2019 | PA4144 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein precursor; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | 0.884 |
PA2019 | PA4374 | PA2019 | PA4374 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein precursor; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.907 |
PA2019 | mexA | PA2019 | PA0425 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein precursor; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.918 |
PA2019 | mexB | PA2019 | PA0426 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein precursor; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.968 |
PA2019 | oprJ | PA2019 | PA4597 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein precursor; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Multidrug efflux outer membrane protein OprJ precursor; Channel-forming component of a multidrug resistance efflux pump; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | 0.808 |
PA2019 | oprM | PA2019 | PA0427 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein precursor; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor; The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane co [...] | 0.964 |
PA2019 | oprN | PA2019 | PA2495 | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein precursor; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Multidrug efflux outer membrane protein OprN precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.738 |
PA4142 | PA4144 | PA4142 | PA4144 | Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | 0.957 |
PA4142 | mexA | PA4142 | PA0425 | Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.934 |
PA4142 | mexB | PA4142 | PA0426 | Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.966 |
PA4142 | mexC | PA4142 | PA4599 | Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexC precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.522 |
PA4142 | mexE | PA4142 | PA2493 | Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexE precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.577 |
PA4142 | oprJ | PA4142 | PA4597 | Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Multidrug efflux outer membrane protein OprJ precursor; Channel-forming component of a multidrug resistance efflux pump; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | 0.879 |
PA4142 | oprM | PA4142 | PA0427 | Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor; The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane co [...] | 0.959 |
PA4142 | oprN | PA4142 | PA2495 | Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Multidrug efflux outer membrane protein OprN precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.881 |
PA4144 | PA2019 | PA4144 | PA2019 | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein precursor; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.884 |
PA4144 | PA4142 | PA4144 | PA4142 | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.957 |
PA4144 | PA4374 | PA4144 | PA4374 | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | Probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.927 |
PA4144 | mexA | PA4144 | PA0425 | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.941 |
PA4144 | mexB | PA4144 | PA0426 | Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.932 |