STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumC2Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)    
Predicted Functional Partners:
PA4333
Probable fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.985
sdhA
Succinate dehydrogenase (A subunit); Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 0.979
mqoA
Malate:quinone oxidoreductase; Product name confidence: Class 2 (High similarity to functionally studied protein).
    
 0.963
PA0853
Probable oxidoreductase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
  
 0.957
sdhB
Succinate dehydrogenase (B subunit); Product name confidence: Class 2 (High similarity to functionally studied protein).
  
 0.956
sdhC
Succinate dehydrogenase (C subunit); Product name confidence: Class 2 (High similarity to functionally studied protein).
   
 
 0.950
maeA
Probable malic enzyme; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the malic enzymes family.
  
 
 0.949
mqoB
Malate:quinone oxidoreductase; Product name confidence: Class 2 (High similarity to functionally studied protein).
    
 0.947
PA5046
Malic enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein).
 
 
 0.947
gltA
Citrate synthase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
   
 0.943
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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