node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA2531 | aroQ | PA2531 | PA5184 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Hypothetical protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. The joint presence of this enzyme together with cyclohexadienyl dehydratase and aromatic aminotransferase in the periplasmic compartment comprises a complete three-step chorismate to phenylalanine pathway and accounts for the so called hidden overflow pathway to phenylalanine in P.aeruginosa, in which two possible routes for it exists, namely either via phenylpyruvate or L-arogenate. | 0.801 |
PA2531 | hisC2 | PA2531 | PA3165 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Histidinol-phosphate aminotransferase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.939 |
PA2531 | hpd | PA2531 | PA0865 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 4-hydroxyphenylpyruvate dioxygenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the 4HPPD family. | 0.908 |
PA2531 | maiA | PA2531 | PA2007 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Maleylacetoacetate isomerase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the GST superfamily. Zeta family. | 0.404 |
PA2531 | pheA | PA2531 | PA3166 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. | 0.960 |
PA2531 | phhA | PA2531 | PA0872 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Phenylalanine-4-hydroxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | 0.936 |
PA2531 | phhC | PA2531 | PA0870 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Aromatic amino acid aminotransferase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.962 |
PA2531 | quiC1 | PA2531 | PA0242 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Hypothetical protein; Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways. Is required for growth on either quinate or shikimate as a sole carbon source. | 0.923 |
aroQ | PA2531 | PA5184 | PA2531 | Hypothetical protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. The joint presence of this enzyme together with cyclohexadienyl dehydratase and aromatic aminotransferase in the periplasmic compartment comprises a complete three-step chorismate to phenylalanine pathway and accounts for the so called hidden overflow pathway to phenylalanine in P.aeruginosa, in which two possible routes for it exists, namely either via phenylpyruvate or L-arogenate. | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.801 |
aroQ | pheA | PA5184 | PA3166 | Hypothetical protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. The joint presence of this enzyme together with cyclohexadienyl dehydratase and aromatic aminotransferase in the periplasmic compartment comprises a complete three-step chorismate to phenylalanine pathway and accounts for the so called hidden overflow pathway to phenylalanine in P.aeruginosa, in which two possible routes for it exists, namely either via phenylpyruvate or L-arogenate. | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. | 0.951 |
aroQ | phhA | PA5184 | PA0872 | Hypothetical protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. The joint presence of this enzyme together with cyclohexadienyl dehydratase and aromatic aminotransferase in the periplasmic compartment comprises a complete three-step chorismate to phenylalanine pathway and accounts for the so called hidden overflow pathway to phenylalanine in P.aeruginosa, in which two possible routes for it exists, namely either via phenylpyruvate or L-arogenate. | Phenylalanine-4-hydroxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | 0.409 |
aroQ | phhC | PA5184 | PA0870 | Hypothetical protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. The joint presence of this enzyme together with cyclohexadienyl dehydratase and aromatic aminotransferase in the periplasmic compartment comprises a complete three-step chorismate to phenylalanine pathway and accounts for the so called hidden overflow pathway to phenylalanine in P.aeruginosa, in which two possible routes for it exists, namely either via phenylpyruvate or L-arogenate. | Aromatic amino acid aminotransferase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.942 |
fahA | hpd | PA2008 | PA0865 | Fumarylacetoacetase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 4-hydroxyphenylpyruvate dioxygenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the 4HPPD family. | 0.991 |
fahA | maiA | PA2008 | PA2007 | Fumarylacetoacetase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Maleylacetoacetate isomerase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the GST superfamily. Zeta family. | 0.999 |
fahA | phhA | PA2008 | PA0872 | Fumarylacetoacetase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Phenylalanine-4-hydroxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | 0.958 |
fahA | phhB | PA2008 | PA0871 | Fumarylacetoacetase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA. | 0.781 |
fahA | phhC | PA2008 | PA0870 | Fumarylacetoacetase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Aromatic amino acid aminotransferase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.957 |
fahA | quiC1 | PA2008 | PA0242 | Fumarylacetoacetase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Hypothetical protein; Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways. Is required for growth on either quinate or shikimate as a sole carbon source. | 0.934 |
hisC2 | PA2531 | PA3165 | PA2531 | Histidinol-phosphate aminotransferase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.939 |
hisC2 | hpd | PA3165 | PA0865 | Histidinol-phosphate aminotransferase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 4-hydroxyphenylpyruvate dioxygenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the 4HPPD family. | 0.935 |