STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phhCAromatic amino acid aminotransferase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (399 aa)    
Predicted Functional Partners:
phhA
Phenylalanine-4-hydroxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
  
 
 0.999
phhB
Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA.
  
  
 0.997
hpd
4-hydroxyphenylpyruvate dioxygenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the 4HPPD family.
  
 
 0.995
quiC1
Hypothetical protein; Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways. Is required for growth on either quinate or shikimate as a sole carbon source.
  
 
 0.975
maiA
Maleylacetoacetate isomerase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the GST superfamily. Zeta family.
  
  
 0.969
PA2531
Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
   
 
 0.962
hisC2
Histidinol-phosphate aminotransferase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
   
 
 0.962
fahA
Fumarylacetoacetase; Product name confidence: Class 2 (High similarity to functionally studied protein).
  
 
 0.957
pheA
Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
  
 
 0.951
aroQ
Hypothetical protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. The joint presence of this enzyme together with cyclohexadienyl dehydratase and aromatic aminotransferase in the periplasmic compartment comprises a complete three-step chorismate to phenylalanine pathway and accounts for the so called hidden overflow pathway to phenylalanine in P.aeruginosa, in which two possible routes for it exists, namely either via phenylpyruvate or L-arogenate.
    
 0.942
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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