Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| exoS | exoT | PA3841 | PA0044 | Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.907 |
| exoS | lasA | PA3841 | PA1871 | Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | LasA protease precursor; Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly- Gly-|-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a [...] | 0.881 |
| exoS | lasB | PA3841 | PA3724 | Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Elastase LasB; Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections. | 0.883 |
| exoS | lasI | PA3841 | PA1432 | Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Autoinducer synthesis protein LasI; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation. | 0.768 |
| exoS | lasR | PA3841 | PA1430 | Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Transcriptional regulator LasR; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer; Belongs to the autoinducer-regulated transcriptional regulatory protein family. | 0.807 |
| exoS | piv | PA3841 | PA4175 | Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Protease IV; Lysine-specific endoprotease. Involved in corneal virulence; Belongs to the peptidase S1 family. | 0.588 |
| exoS | plcH | PA3841 | PA0844 | Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Hemolytic phospholipase C precursor; Hydrolyzes sphingomyelin in addition to phosphatidylcholine. | 0.882 |
| exoS | plcN | PA3841 | PA3319 | Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Non-hemolytic phospholipase C precursor; Hydrolyzes phosphatidylserine as well as phosphatidylcholine. | 0.858 |
| exoS | toxA | PA3841 | PA1148 | Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Exotoxin A precursor; An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38. | 0.883 |
| exoT | exoS | PA0044 | PA3841 | Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.907 |
| exoT | lasA | PA0044 | PA1871 | Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | LasA protease precursor; Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly- Gly-|-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a [...] | 0.822 |
| exoT | lasB | PA0044 | PA3724 | Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Elastase LasB; Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections. | 0.882 |
| exoT | lasI | PA0044 | PA1432 | Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Autoinducer synthesis protein LasI; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation. | 0.588 |
| exoT | lasR | PA0044 | PA1430 | Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Transcriptional regulator LasR; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer; Belongs to the autoinducer-regulated transcriptional regulatory protein family. | 0.700 |
| exoT | piv | PA0044 | PA4175 | Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Protease IV; Lysine-specific endoprotease. Involved in corneal virulence; Belongs to the peptidase S1 family. | 0.563 |
| exoT | plcH | PA0044 | PA0844 | Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Hemolytic phospholipase C precursor; Hydrolyzes sphingomyelin in addition to phosphatidylcholine. | 0.800 |
| exoT | plcN | PA0044 | PA3319 | Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Non-hemolytic phospholipase C precursor; Hydrolyzes phosphatidylserine as well as phosphatidylcholine. | 0.699 |
| exoT | toxA | PA0044 | PA1148 | Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Exotoxin A precursor; An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38. | 0.883 |
| lasA | exoS | PA1871 | PA3841 | LasA protease precursor; Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly- Gly-|-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a [...] | Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.881 |
| lasA | exoT | PA1871 | PA0044 | LasA protease precursor; Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly- Gly-|-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a [...] | Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.822 |
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