STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aprDAlkaline protease secretion protein AprD; Involved in the secretion of alkaline protease; Belongs to the ABC transporter superfamily. Alkaline protease exporter (TC 3.A.1.110.4) family. (593 aa)    
Predicted Functional Partners:
aprE
Alkaline protease secretion protein AprE; Involved in the secretion of alkaline protease; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 0.999
aprF
Alkaline protease secretion outer membrane protein AprF precursor; Involved in the secretion of alkaline protease; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
 
  
 0.998
aprA
Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family.
 
 
 0.984
PA1245
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
  
    0.951
aprI
Alkaline proteinase inhibitor AprI; Inhibitor of the alkaline protease. It forms a non-covalent bond with the protease and may prevent its autocatalytic cleavage in the periplasm (By similarity).
  
  
 0.910
hasD
Transport protein HasD; Product name confidence: Class 2 (High similarity to functionally studied protein).
  
 
0.905
hasE
Metalloprotease secretion protein; Product name confidence: Class 2 (High similarity to functionally studied protein).
  
 0.807
metN2
Probable ATP-binding component of ABC transporter; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
 
     
0.719
PA1877
Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
   
 0.659
PA3404
Probable outer membrane protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
   
 0.531
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.