node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA1254 | PA1255 | PA1254 | PA1255 | Probable dihydrodipicolinate synthetase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the DapA family. | Hypothetical protein; Probably catalyzes the dehydration of trans-3-hydroxy-L- proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Is likely involved in a degradation pathway that converts t3LHyp to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Displays neither trans-4-hydroxy-L-proline (t4LHyp) epimerase nor proline racemase activity. | 0.859 |
PA1254 | PA1259 | PA1254 | PA1259 | Probable dihydrodipicolinate synthetase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the DapA family. | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | 0.642 |
PA1254 | lhpD | PA1254 | PA1252 | Probable dihydrodipicolinate synthetase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the DapA family. | Probable L-malate dehydrogenase; Catalyzes the reduction of both Delta(1)-pyrroline-2- carboxylate (Pyr2C) and Delta(1)-piperideine-2-carboxylate (Pip2C) to L-proline and L-pipecolate, respectively, using NADPH as the electron donor. Cannot use NADH instead of NADPH. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Can also catalyze the reverse oxidation reactions, albeit at a much lower rate. Is also able to use Delta(1)-pyrroline- (4S)-hydroxy-2-carboxyl [...] | 0.825 |
PA1254 | thiO | PA1254 | PA4548 | Probable dihydrodipicolinate synthetase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the DapA family. | Probable D-amino acid oxidase; Catalyzes the oxidation of glycine, leading to glyoxyl imine and hydrogen peroxide as primary products; glyoxyl imine is used for the biosynthesis of the thiazole ring of thiamine. Otherwise, glyoxyl imine is spontaneously hydrolyzed in water to produce glyoxylate and ammonia. Can also use sarcosine (N-methylglycine) as substrate. Belongs to the DAO family. ThiO subfamily. | 0.608 |
PA1255 | PA1254 | PA1255 | PA1254 | Hypothetical protein; Probably catalyzes the dehydration of trans-3-hydroxy-L- proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Is likely involved in a degradation pathway that converts t3LHyp to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Displays neither trans-4-hydroxy-L-proline (t4LHyp) epimerase nor proline racemase activity. | Probable dihydrodipicolinate synthetase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the DapA family. | 0.859 |
PA1255 | PA1259 | PA1255 | PA1259 | Hypothetical protein; Probably catalyzes the dehydration of trans-3-hydroxy-L- proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Is likely involved in a degradation pathway that converts t3LHyp to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Displays neither trans-4-hydroxy-L-proline (t4LHyp) epimerase nor proline racemase activity. | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | 0.997 |
PA1255 | lhpD | PA1255 | PA1252 | Hypothetical protein; Probably catalyzes the dehydration of trans-3-hydroxy-L- proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Is likely involved in a degradation pathway that converts t3LHyp to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Displays neither trans-4-hydroxy-L-proline (t4LHyp) epimerase nor proline racemase activity. | Probable L-malate dehydrogenase; Catalyzes the reduction of both Delta(1)-pyrroline-2- carboxylate (Pyr2C) and Delta(1)-piperideine-2-carboxylate (Pip2C) to L-proline and L-pipecolate, respectively, using NADPH as the electron donor. Cannot use NADH instead of NADPH. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Can also catalyze the reverse oxidation reactions, albeit at a much lower rate. Is also able to use Delta(1)-pyrroline- (4S)-hydroxy-2-carboxyl [...] | 0.947 |
PA1259 | PA1254 | PA1259 | PA1254 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Probable dihydrodipicolinate synthetase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the DapA family. | 0.642 |
PA1259 | PA1255 | PA1259 | PA1255 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Hypothetical protein; Probably catalyzes the dehydration of trans-3-hydroxy-L- proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Is likely involved in a degradation pathway that converts t3LHyp to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Displays neither trans-4-hydroxy-L-proline (t4LHyp) epimerase nor proline racemase activity. | 0.997 |
PA1259 | lhpD | PA1259 | PA1252 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Probable L-malate dehydrogenase; Catalyzes the reduction of both Delta(1)-pyrroline-2- carboxylate (Pyr2C) and Delta(1)-piperideine-2-carboxylate (Pip2C) to L-proline and L-pipecolate, respectively, using NADPH as the electron donor. Cannot use NADH instead of NADPH. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Can also catalyze the reverse oxidation reactions, albeit at a much lower rate. Is also able to use Delta(1)-pyrroline- (4S)-hydroxy-2-carboxyl [...] | 0.954 |
PA1400 | PA5046 | PA1400 | PA5046 | Probable pyruvate carboxylase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Malic enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.704 |
PA1400 | lhpD | PA1400 | PA1252 | Probable pyruvate carboxylase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Probable L-malate dehydrogenase; Catalyzes the reduction of both Delta(1)-pyrroline-2- carboxylate (Pyr2C) and Delta(1)-piperideine-2-carboxylate (Pip2C) to L-proline and L-pipecolate, respectively, using NADPH as the electron donor. Cannot use NADH instead of NADPH. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Can also catalyze the reverse oxidation reactions, albeit at a much lower rate. Is also able to use Delta(1)-pyrroline- (4S)-hydroxy-2-carboxyl [...] | 0.626 |
PA1400 | maeA | PA1400 | PA3471 | Probable pyruvate carboxylase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Probable malic enzyme; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the malic enzymes family. | 0.793 |
PA2026 | lhpD | PA2026 | PA1252 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences); To E.coli YfeH. | Probable L-malate dehydrogenase; Catalyzes the reduction of both Delta(1)-pyrroline-2- carboxylate (Pyr2C) and Delta(1)-piperideine-2-carboxylate (Pip2C) to L-proline and L-pipecolate, respectively, using NADPH as the electron donor. Cannot use NADH instead of NADPH. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Can also catalyze the reverse oxidation reactions, albeit at a much lower rate. Is also able to use Delta(1)-pyrroline- (4S)-hydroxy-2-carboxyl [...] | 0.765 |
PA2393 | lhpD | PA2393 | PA1252 | Probable dipeptidase precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Probable L-malate dehydrogenase; Catalyzes the reduction of both Delta(1)-pyrroline-2- carboxylate (Pyr2C) and Delta(1)-piperideine-2-carboxylate (Pip2C) to L-proline and L-pipecolate, respectively, using NADPH as the electron donor. Cannot use NADH instead of NADPH. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Can also catalyze the reverse oxidation reactions, albeit at a much lower rate. Is also able to use Delta(1)-pyrroline- (4S)-hydroxy-2-carboxyl [...] | 0.638 |
PA5046 | PA1400 | PA5046 | PA1400 | Malic enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). | Probable pyruvate carboxylase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.704 |
PA5046 | lhpD | PA5046 | PA1252 | Malic enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). | Probable L-malate dehydrogenase; Catalyzes the reduction of both Delta(1)-pyrroline-2- carboxylate (Pyr2C) and Delta(1)-piperideine-2-carboxylate (Pip2C) to L-proline and L-pipecolate, respectively, using NADPH as the electron donor. Cannot use NADH instead of NADPH. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Can also catalyze the reverse oxidation reactions, albeit at a much lower rate. Is also able to use Delta(1)-pyrroline- (4S)-hydroxy-2-carboxyl [...] | 0.801 |
PA5046 | maeA | PA5046 | PA3471 | Malic enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). | Probable malic enzyme; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the malic enzymes family. | 0.936 |
PA5396 | lhpD | PA5396 | PA1252 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Probable L-malate dehydrogenase; Catalyzes the reduction of both Delta(1)-pyrroline-2- carboxylate (Pyr2C) and Delta(1)-piperideine-2-carboxylate (Pip2C) to L-proline and L-pipecolate, respectively, using NADPH as the electron donor. Cannot use NADH instead of NADPH. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Can also catalyze the reverse oxidation reactions, albeit at a much lower rate. Is also able to use Delta(1)-pyrroline- (4S)-hydroxy-2-carboxyl [...] | 0.670 |
lhpD | PA1254 | PA1252 | PA1254 | Probable L-malate dehydrogenase; Catalyzes the reduction of both Delta(1)-pyrroline-2- carboxylate (Pyr2C) and Delta(1)-piperideine-2-carboxylate (Pip2C) to L-proline and L-pipecolate, respectively, using NADPH as the electron donor. Cannot use NADH instead of NADPH. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Can also catalyze the reverse oxidation reactions, albeit at a much lower rate. Is also able to use Delta(1)-pyrroline- (4S)-hydroxy-2-carboxyl [...] | Probable dihydrodipicolinate synthetase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the DapA family. | 0.825 |