STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
oprFMajor porin and structural outer membrane porin OprF precursor; Has porin activity, forming small water-filled channels. Also has a structural role in determining cell shape and ability to grow in low-osmolarity medium; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. (350 aa)    
Predicted Functional Partners:
oprD
Basic amino acid, basic peptide and imipenem outer membrane porin OprD precursor; Porin with a specificity for basic amino acids. Also possesses serine protease activity; Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.
  
 
 0.971
oprI
Outer membrane lipoprotein OprI precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
   
  
 0.967
oprH
PhoP/Q and low Mg2+ inducible outer membrane protein H1 precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
  
 
 0.962
sigX
ECF sigma factor SigX; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the sigma-70 factor family. ECF subfamily.
 
  
 0.961
oprE
Anaerobically-induced outer membrane porin OprE precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
  
  
 0.960
cmpX
Conserved cytoplasmic membrane protein, CmpX protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.955
oprG
Outer membrane protein OprG precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
   
  
 0.944
oprB
Glucose/carbohydrate outer membrane porin OprB precursor; Substrate-selective channel for a variety of different sugars. Could potentially facilitate the diffusion of diverse compounds, dependent on the presence of a hydroxyl group, but is presumably restricted to carbohydrates. Involved in the transport of glucose, mannitol, fructose and glycerol (sugars able to support the growth of P.aeruginosa). Facilitates glucose diffusion across the outer membrane.
   
 
 0.919
fliC
Flagellin type B; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
   
  
 0.908
oprP
Phosphate-specific outer membrane porin OprP precursor; Anion specific, the binding site has higher affinity for phosphate than chloride ions. Porin O has a higher affinity for polyphosphates (tripolyphosphate and pyrophosphate) while porin P has a higher affinity for orthophosphate.
  
  
 0.906
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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