STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ptxRTranscriptional regulator PtxR; Transcriptional activator of the toxA (exotoxin) and regA genes. (312 aa)    
Predicted Functional Partners:
ptxS
Transcriptional regulator PtxS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
      
 0.883
toxA
Exotoxin A precursor; An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38.
      
 0.882
toxR
Transcriptional regulator ToxR; Positive regulation of toxA gene transcription.
      
 0.880
PA2076
Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the LysR transcriptional regulatory family.
  
  
 0.855
PA2206
Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the LysR transcriptional regulatory family.
  
   
 0.784
pvdS
Sigma factor PvdS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the sigma-70 factor family. ECF subfamily.
      
 0.769
PA5085
Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the LysR transcriptional regulatory family.
  
     0.730
vfr
Transcriptional regulator Vfr; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production.
   
  
 0.705
catR
Transcriptional regulator CatR; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the LysR transcriptional regulatory family.
  
     0.693
oxyR
OxyR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa; Belongs to the LysR transcriptional regulatory family.
  
   
 0.664
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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