node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA3131 | PA3896 | PA3131 | PA3896 | Probable aldolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Probable 2-hydroxyacid dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.904 |
PA3131 | aceA | PA3131 | PA2634 | Probable aldolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | 0.906 |
PA3131 | eda | PA3131 | PA3181 | Probable aldolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | 0.912 |
PA3131 | gcl | PA3131 | PA1502 | Probable aldolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Glyoxylate carboligase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the TPP enzyme family. | 0.900 |
PA3131 | glcB | PA3131 | PA0482 | Probable aldolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.909 |
PA3131 | glcF | PA3131 | PA5353 | Probable aldolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Glycolate oxidase subunit GlcF; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.904 |
PA3131 | hprA | PA3131 | PA4626 | Probable aldolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Glycerate dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.903 |
PA3896 | PA3131 | PA3896 | PA3131 | Probable 2-hydroxyacid dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Probable aldolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.904 |
PA3896 | aceA | PA3896 | PA2634 | Probable 2-hydroxyacid dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | 0.909 |
PA3896 | eda | PA3896 | PA3181 | Probable 2-hydroxyacid dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | 0.903 |
PA3896 | gcl | PA3896 | PA1502 | Probable 2-hydroxyacid dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Glyoxylate carboligase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the TPP enzyme family. | 0.902 |
PA3896 | glcB | PA3896 | PA0482 | Probable 2-hydroxyacid dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.916 |
PA3896 | glcF | PA3896 | PA5353 | Probable 2-hydroxyacid dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Glycolate oxidase subunit GlcF; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.907 |
PA3896 | hprA | PA3896 | PA4626 | Probable 2-hydroxyacid dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Glycerate dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.921 |
aceA | PA3131 | PA2634 | PA3131 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | Probable aldolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.906 |
aceA | PA3896 | PA2634 | PA3896 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | Probable 2-hydroxyacid dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.909 |
aceA | aceK | PA2634 | PA1376 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. | 0.930 |
aceA | acnA | PA2634 | PA1562 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | Aconitate hydratase 1; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis- aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein. | 0.953 |
aceA | acnB | PA2634 | PA1787 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | Aconitate hydratase 2; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Catalyzes the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnB functions as a RNA-binding regulatory protein. | 0.934 |
aceA | eda | PA2634 | PA3181 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | 0.919 |