node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA0506 | etfB | PA0506 | PA2952 | Probable acyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Electron transfer flavoprotein beta-subunit; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). | 0.871 |
PA0506 | psrA | PA0506 | PA3006 | Probable acyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Transcriptional regulator PsrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.722 |
PA3004 | nagZ | PA3004 | PA3005 | 5-methylthioadenosine phosphorylase MtnP; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. Involved in quorum sensing; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | beta-N-acetyl-D-glucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides (By similarity). Contributes to intrinsic fosfomycin resistance in P.aeruginosa ; Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.877 |
PA3004 | psrA | PA3004 | PA3006 | 5-methylthioadenosine phosphorylase MtnP; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. Involved in quorum sensing; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | Transcriptional regulator PsrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.657 |
anr | gacA | PA1544 | PA2586 | Transcriptional regulator Anr; Transcriptional activator of anaerobic gene expression. | Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. | 0.566 |
anr | gacS | PA1544 | PA0928 | Transcriptional regulator Anr; Transcriptional activator of anaerobic gene expression. | Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.658 |
anr | mvaT | PA1544 | PA4315 | Transcriptional regulator Anr; Transcriptional activator of anaerobic gene expression. | Transcriptional regulator MvaT, P16 subunit; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.445 |
anr | psrA | PA1544 | PA3006 | Transcriptional regulator Anr; Transcriptional activator of anaerobic gene expression. | Transcriptional regulator PsrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.623 |
anr | rpoS | PA1544 | PA3622 | Transcriptional regulator Anr; Transcriptional activator of anaerobic gene expression. | Sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. | 0.833 |
etfB | PA0506 | PA2952 | PA0506 | Electron transfer flavoprotein beta-subunit; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). | Probable acyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.871 |
etfB | psrA | PA2952 | PA3006 | Electron transfer flavoprotein beta-subunit; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). | Transcriptional regulator PsrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.585 |
gacA | anr | PA2586 | PA1544 | Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. | Transcriptional regulator Anr; Transcriptional activator of anaerobic gene expression. | 0.566 |
gacA | gacS | PA2586 | PA0928 | Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. | Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.999 |
gacA | mvaT | PA2586 | PA4315 | Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. | Transcriptional regulator MvaT, P16 subunit; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.708 |
gacA | psrA | PA2586 | PA3006 | Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. | Transcriptional regulator PsrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.742 |
gacA | rpoS | PA2586 | PA3622 | Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. | Sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. | 0.904 |
gacS | anr | PA0928 | PA1544 | Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). | Transcriptional regulator Anr; Transcriptional activator of anaerobic gene expression. | 0.658 |
gacS | gacA | PA0928 | PA2586 | Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). | Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. | 0.999 |
gacS | psrA | PA0928 | PA3006 | Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). | Transcriptional regulator PsrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.750 |
gacS | rpoS | PA0928 | PA3622 | Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). | Sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. | 0.930 |