STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadKConserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (295 aa)    
Predicted Functional Partners:
pntAB
Putative NAD(P) transhydrogenase, subunit alpha part 2.
     
 0.989
nadE
NH3-dependent NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
  
 
 0.967
sth
Soluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  
 
 0.936
nadD
Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
 
 0.932
cobB1
Probable cobalamin biosynthetic protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily.
  
 
 0.921
cobB2
Hypothetical protein; NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form; Belongs to the sirtuin family. Class III subfamily.
  
 
 0.921
pntAA
Putative NAD(P) transhydrogenase, subunit alpha part 1; Product name confidence: Class 2 (High similarity to functionally studied protein).
   
 
 0.919
pntB
Pyridine nucleotide transhydrogenase, beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.910
PA0935
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
 
 0.906
nudC
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
 
 0.905
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.