node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA2531 | hisB | PA2531 | PA5143 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.989 |
PA2531 | hisC2 | PA2531 | PA3165 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Histidinol-phosphate aminotransferase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.939 |
PA2531 | hisD | PA2531 | PA4448 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.926 |
PA2531 | hisF2 | PA2531 | PA3151 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.878 |
PA2531 | hisH1 | PA2531 | PA5142 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.859 |
PA2531 | hisH2 | PA2531 | PA3152 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.948 |
PA2531 | hpd | PA2531 | PA0865 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 4-hydroxyphenylpyruvate dioxygenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the 4HPPD family. | 0.908 |
PA2531 | pheA | PA2531 | PA3166 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. | 0.960 |
PA2531 | phhA | PA2531 | PA0872 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Phenylalanine-4-hydroxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. | 0.936 |
PA2531 | phhC | PA2531 | PA0870 | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Aromatic amino acid aminotransferase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.962 |
hisB | PA2531 | PA5143 | PA2531 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.989 |
hisB | hisC2 | PA5143 | PA3165 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Histidinol-phosphate aminotransferase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.998 |
hisB | hisD | PA5143 | PA4448 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF2 | PA5143 | PA3151 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.997 |
hisB | hisH1 | PA5143 | PA5142 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.999 |
hisB | hisH2 | PA5143 | PA3152 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.996 |
hisB | pheA | PA5143 | PA3166 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. | 0.654 |
hisC2 | PA2531 | PA3165 | PA2531 | Histidinol-phosphate aminotransferase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.939 |
hisC2 | hisB | PA3165 | PA5143 | Histidinol-phosphate aminotransferase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.998 |
hisC2 | hisD | PA3165 | PA4448 | Histidinol-phosphate aminotransferase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.991 |