node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA2323 | eda | PA2323 | PA3181 | Probable glyceraldehyde-3-phosphate dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | 0.931 |
PA2323 | gapA | PA2323 | PA3195 | Probable glyceraldehyde-3-phosphate dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Glyceraldehyde 3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. | 0.930 |
PA2323 | glk | PA2323 | PA3193 | Probable glyceraldehyde-3-phosphate dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Glucokinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the bacterial glucokinase family. | 0.827 |
PA2323 | pgi | PA2323 | PA4732 | Probable glyceraldehyde-3-phosphate dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Glucose-6-phosphate isomerase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.878 |
PA2323 | zwf | PA2323 | PA3183 | Probable glyceraldehyde-3-phosphate dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. Can utilize either NADP(+) or NAD(+). Belongs to the glucose-6-phosphate dehydrogenase family. | 0.831 |
PA2323 | zwf-2 | PA2323 | PA5439 | Probable glyceraldehyde-3-phosphate dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Probable glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.821 |
eda | PA2323 | PA3181 | PA2323 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Probable glyceraldehyde-3-phosphate dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.931 |
eda | edd | PA3181 | PA3194 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.999 |
eda | gapA | PA3181 | PA3195 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Glyceraldehyde 3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. | 0.986 |
eda | glk | PA3181 | PA3193 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Glucokinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the bacterial glucokinase family. | 0.997 |
eda | gltR | PA3181 | PA3192 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Two-component response regulator GltR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.927 |
eda | hexR | PA3181 | PA3184 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Probable transcriptional regulator; Involved in regulation of glucose metabolism. Transcriptional repressor of the gap-1 gene and of the edd-glk-gltR-2 and zwf-pgl-eda operons. Acts by binding directly to an inverted pseudopalindromic sequence in the promoter region. | 0.970 |
eda | pgi | PA3181 | PA4732 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Glucose-6-phosphate isomerase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.938 |
eda | pgl | PA3181 | PA3182 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | 0.995 |
eda | zwf | PA3181 | PA3183 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. Can utilize either NADP(+) or NAD(+). Belongs to the glucose-6-phosphate dehydrogenase family. | 0.998 |
eda | zwf-2 | PA3181 | PA5439 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Probable glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.956 |
edd | eda | PA3194 | PA3181 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | 0.999 |
edd | gapA | PA3194 | PA3195 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Glyceraldehyde 3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. | 0.983 |
edd | glk | PA3194 | PA3193 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Glucokinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the bacterial glucokinase family. | 0.993 |
edd | gltR | PA3194 | PA3192 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Two-component response regulator GltR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.925 |