node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
eda | edd | PA3181 | PA3194 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.999 |
eda | gapA | PA3181 | PA3195 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Glyceraldehyde 3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. | 0.986 |
eda | gcd | PA3181 | PA2290 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Glucose dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.727 |
eda | glk | PA3181 | PA3193 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Glucokinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the bacterial glucokinase family. | 0.997 |
eda | gltR | PA3181 | PA3192 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Two-component response regulator GltR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.927 |
eda | pgi | PA3181 | PA4732 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Glucose-6-phosphate isomerase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.938 |
eda | pgl | PA3181 | PA3182 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | 0.995 |
eda | zwf | PA3181 | PA3183 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. Can utilize either NADP(+) or NAD(+). Belongs to the glucose-6-phosphate dehydrogenase family. | 0.998 |
eda | zwf-2 | PA3181 | PA5439 | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | Probable glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.956 |
edd | eda | PA3194 | PA3181 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | 0.999 |
edd | gapA | PA3194 | PA3195 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Glyceraldehyde 3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. | 0.983 |
edd | gcd | PA3194 | PA2290 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Glucose dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.714 |
edd | glk | PA3194 | PA3193 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Glucokinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the bacterial glucokinase family. | 0.993 |
edd | gltR | PA3194 | PA3192 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Two-component response regulator GltR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.925 |
edd | pgi | PA3194 | PA4732 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Glucose-6-phosphate isomerase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.733 |
edd | pgl | PA3194 | PA3182 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | 0.998 |
edd | tktA | PA3194 | PA0548 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.501 |
edd | zwf | PA3194 | PA3183 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. Can utilize either NADP(+) or NAD(+). Belongs to the glucose-6-phosphate dehydrogenase family. | 0.996 |
edd | zwf-2 | PA3194 | PA5439 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Probable glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.974 |
gapA | eda | PA3195 | PA3181 | Glyceraldehyde 3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. | 2-keto-3-deoxy-6-phosphogluconate aldolase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the KHG/KDPG aldolase family. | 0.986 |