STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppgLPeriplasmic gluconolactonase, PpgL; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (388 aa)    
Predicted Functional Partners:
nmoA
Hypothetical protein; Nitronate monooxygenase that uses molecular oxygen to catalyze the oxidative denitrification of alkyl nitronates. The toxin propionate 3-nitronate (P3N) is the best substrate (and the presumed physiological substrate), but this enzyme is also active on other primary and secondary nitronates such as propyl-1-nitronate, ethylnitronate, pentyl-1-nitronate, butyl-1-nitronate and propyl-2- nitronate. Is likely involved in the degradation of P3N, that allows P.aeruginosa PAO1 to grow on 3-nitropropionate/P3N as the sole nitrogen source. Also functions in the detoxificat [...]
  
  
 0.859
nmoR
Probable transcriptional regulator; Represses its own transcription and the expression of nmoA, a nitronate monooxygenase. The nmoA-nmoR intergenic region is the sole direct binding site of NmoR across the P.aeruginosa PAO1 genome. Other genes seem also to be under negative control of NmoR, especially PA1225 and the hemO gene; Belongs to the LysR transcriptional regulatory family.
  
  
 0.809
PA1225
Probable NAD(P)H dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
      
 0.802
ddlA
D-alanine-D-alanine ligase A; Cell wall formation.
  
  
 0.781
gcd
Glucose dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein).
 
  
 0.619
PA2858
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
      
 0.588
PA0989
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
      
 0.587
PA2265
Gluconate dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein).
   
 
  0.500
PA0853
Probable oxidoreductase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
   
    0.461
PA0490
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
    0.455
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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