STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pchRTranscriptional regulator PchR; Positive activator of the genes for pyochelin and ferripyochelin receptors. (296 aa)    
Predicted Functional Partners:
fptA
Fe(III)-pyochelin outer membrane receptor precursor; High-affinity outer membrane receptor required for the transport of Fe(3+)-pyochelin.
 
  
 0.975
pchF
Pyochelin synthetase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.938
pvdS
Sigma factor PvdS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the sigma-70 factor family. ECF subfamily.
  
  
 0.933
pchA
Salicylate biosynthesis isochorismate synthase; Involved in the conversion of chorismate to salicylate.
 
  
 0.927
pchD
Pyochelin biosynthesis protein PchD; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.921
PA4218
Probable transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
  
 0.915
pchB
Salicylate biosynthesis protein PchB; Involved in the incorporation of salicylate into the siderophore pyochelin. Catalyzes the elimination of the enolpyruvyl side chain from isochorismate to yield salicylate and pyruvate via a rare pericyclic hydrogen transfer mechanism from C2 to C5. PchB also catalyzes the nonphysiological Claisen rearrangement of chorismate to prephenate in which the pyruvylenol tail is transferred from a C3 ether linkage to a C1-C9 linkage.
 
  
 0.910
pchG
Pyochelin biosynthetic protein PchG; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.905
pchE
Dihydroaeruginoic acid synthetase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.902
pchC
Pyochelin biosynthetic protein PchC; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.880
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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