STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
speA-2Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (636 aa)    
Predicted Functional Partners:
aguA
Agmatine deiminase; Mediates the hydrolysis of agmatine into N- carbamoylputrescine in the arginine decarboxylase (ADC) pathway of putrescine biosynthesis, a basic polyamine.
 
  
 0.959
ldcA
Lysine-specific pyridoxal 5'-phosphate-dependent carboxylase, LdcA; Plays an essential role in lysine utilization by acting as a lysine decarboxylase.
   
 
 0.944
speE
Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
  
 
 0.942
aruH
Arginine:Pyruvate Transaminase, AruH; Catalyzes the conversion of L-arginine into 2-ketoarginine via transamination. L-arginine is the best substrate, but it can also use L-lysine, L-methionine, L-leucine, ornithine and L-glutamine, which indicates that it may have a broader physiological function in amino acid catabolism.
  
 
  0.907
aruF
Arginine/ornithine succinyltransferase AI subunit; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. Also acts on L-ornithine.
   
 
  0.903
aruG
Arginine/ornithine succinyltransferase AII subunit; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
   
 
  0.901
speC
Ornithine decarboxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the Orn/Lys/Arg decarboxylase class-II family.
  
  
 0.846
argH
Argininosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).
   
 
 0.842
arcA
Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
    
  0.826
speE2
Hypothetical protein; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
     
 0.669
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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