node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA5390 | arcA | PA5390 | PA5171 | Probable peptidic bond hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.912 |
PA5390 | arcB | PA5390 | PA5172 | Probable peptidic bond hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.939 |
PA5390 | argA | PA5390 | PA5204 | Probable peptidic bond hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | N-acetylglutamate synthase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the acetyltransferase family. ArgA subfamily. | 0.794 |
PA5390 | argC | PA5390 | PA0662 | Probable peptidic bond hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. | 0.772 |
PA5390 | argE | PA5390 | PA5206 | Probable peptidic bond hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Acetylornithine deacetylase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.919 |
PA5390 | argF | PA5390 | PA3537 | Probable peptidic bond hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Ornithine carbamoyltransferase, anabolic; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase (ArgG) involved in the final step in arginine biosynthesis. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.962 |
PA5390 | argG | PA5390 | PA3525 | Probable peptidic bond hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Argininosuccinate synthase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.972 |
PA5390 | argJ | PA5390 | PA4402 | Probable peptidic bond hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | 0.932 |
arcA | PA5390 | PA5171 | PA5390 | Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Probable peptidic bond hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.912 |
arcA | arcB | PA5171 | PA5172 | Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.999 |
arcA | arcC | PA5171 | PA5173 | Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Carbamate kinase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.999 |
arcA | arcD | PA5171 | PA5170 | Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Arginine/ornithine antiporter; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. | 0.998 |
arcA | argE | PA5171 | PA5206 | Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Acetylornithine deacetylase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.914 |
arcA | argF | PA5171 | PA3537 | Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Ornithine carbamoyltransferase, anabolic; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase (ArgG) involved in the final step in arginine biosynthesis. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.979 |
arcA | argG | PA5171 | PA3525 | Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Argininosuccinate synthase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.921 |
arcB | PA5390 | PA5172 | PA5390 | Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | Probable peptidic bond hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.939 |
arcB | arcA | PA5172 | PA5171 | Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.999 |
arcB | arcC | PA5172 | PA5173 | Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | Carbamate kinase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.999 |
arcB | arcD | PA5172 | PA5170 | Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | Arginine/ornithine antiporter; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. | 0.993 |
arcB | argA | PA5172 | PA5204 | Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | N-acetylglutamate synthase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the acetyltransferase family. ArgA subfamily. | 0.957 |