STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppxExopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Has also polyphosphate:ADP phosphotransferase activity, catalyzing the production of ATP from ADP and polyP. (506 aa)    
Predicted Functional Partners:
ppk
Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family.
 
 
 0.993
relA
GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.966
ppk2
Conserved hypothetical protein; Uses inorganic polyphosphate (polyP) as a donor to convert ADP to ATP and GDP to GTP. Can also catalyze the synthesis of polyP from ATP or GTP, but the rate of polyP utilization is 75-fold greater than the rate of polyP synthesis; Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
 
  
 0.931
spoT
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.920
PA3455
Conserved hypothetical protein; Uses inorganic polyphosphate (polyP) as a donor to convert AMP to ADP. Can also convert GMP to GDP, with lower efficiency. Cannot dephosphorylate ADP in the presence of polyP.
 
  
 0.892
ppa
Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
  
  
 0.850
phoU
Phosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family.
 
   
 0.794
phoA2
Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family.
     
 0.739
PA4292
Probable phosphate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
     
 0.676
pstS
Phosphate ABC transporter, periplasmic phosphate-binding protein, PstS; Binds 1 inorganic phosphate per subunit with a KD of 0.34 uM. Required for phosphate transport. In strain PAO1 implicated in host cell adhesion; in some virulent strains (e.g. MDR25 which expresses very high levels of this protein) antibody fragments against this protein decrease host cell adhesion and increase transepithelial resistance of human epithelial cell monolayers. Its ability to bind phosphate may allow it to acquire phosphate from its host ; Belongs to the PstS family.
     
 0.650
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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