node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA3455 | ppk | PA3455 | PA5242 | Conserved hypothetical protein; Uses inorganic polyphosphate (polyP) as a donor to convert AMP to ADP. Can also convert GMP to GDP, with lower efficiency. Cannot dephosphorylate ADP in the presence of polyP. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.866 |
PA3455 | ppx | PA3455 | PA5241 | Conserved hypothetical protein; Uses inorganic polyphosphate (polyP) as a donor to convert AMP to ADP. Can also convert GMP to GDP, with lower efficiency. Cannot dephosphorylate ADP in the presence of polyP. | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Has also polyphosphate:ADP phosphotransferase activity, catalyzing the production of ATP from ADP and polyP. | 0.892 |
PA4292 | phoA2 | PA4292 | PA0688 | Probable phosphate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | 0.824 |
PA4292 | phoU | PA4292 | PA5365 | Probable phosphate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Phosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family. | 0.755 |
PA4292 | ppk2 | PA4292 | PA0141 | Probable phosphate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Conserved hypothetical protein; Uses inorganic polyphosphate (polyP) as a donor to convert ADP to ATP and GDP to GTP. Can also catalyze the synthesis of polyP from ATP or GTP, but the rate of polyP utilization is 75-fold greater than the rate of polyP synthesis; Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily. | 0.648 |
PA4292 | ppx | PA4292 | PA5241 | Probable phosphate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Has also polyphosphate:ADP phosphotransferase activity, catalyzing the production of ATP from ADP and polyP. | 0.676 |
PA4292 | pstS | PA4292 | PA5369 | Probable phosphate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Phosphate ABC transporter, periplasmic phosphate-binding protein, PstS; Binds 1 inorganic phosphate per subunit with a KD of 0.34 uM. Required for phosphate transport. In strain PAO1 implicated in host cell adhesion; in some virulent strains (e.g. MDR25 which expresses very high levels of this protein) antibody fragments against this protein decrease host cell adhesion and increase transepithelial resistance of human epithelial cell monolayers. Its ability to bind phosphate may allow it to acquire phosphate from its host ; Belongs to the PstS family. | 0.843 |
phoA2 | PA4292 | PA0688 | PA4292 | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | Probable phosphate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.824 |
phoA2 | phoU | PA0688 | PA5365 | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | Phosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family. | 0.928 |
phoA2 | ppa | PA0688 | PA4031 | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. | 0.498 |
phoA2 | ppk | PA0688 | PA5242 | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.743 |
phoA2 | ppk2 | PA0688 | PA0141 | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | Conserved hypothetical protein; Uses inorganic polyphosphate (polyP) as a donor to convert ADP to ATP and GDP to GTP. Can also catalyze the synthesis of polyP from ATP or GTP, but the rate of polyP utilization is 75-fold greater than the rate of polyP synthesis; Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily. | 0.726 |
phoA2 | ppx | PA0688 | PA5241 | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Has also polyphosphate:ADP phosphotransferase activity, catalyzing the production of ATP from ADP and polyP. | 0.739 |
phoU | PA4292 | PA5365 | PA4292 | Phosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family. | Probable phosphate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.755 |
phoU | phoA2 | PA5365 | PA0688 | Phosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family. | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | 0.928 |
phoU | ppa | PA5365 | PA4031 | Phosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family. | Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. | 0.664 |
phoU | ppk | PA5365 | PA5242 | Phosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.768 |
phoU | ppx | PA5365 | PA5241 | Phosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family. | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Has also polyphosphate:ADP phosphotransferase activity, catalyzing the production of ATP from ADP and polyP. | 0.794 |
phoU | pstS | PA5365 | PA5369 | Phosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family. | Phosphate ABC transporter, periplasmic phosphate-binding protein, PstS; Binds 1 inorganic phosphate per subunit with a KD of 0.34 uM. Required for phosphate transport. In strain PAO1 implicated in host cell adhesion; in some virulent strains (e.g. MDR25 which expresses very high levels of this protein) antibody fragments against this protein decrease host cell adhesion and increase transepithelial resistance of human epithelial cell monolayers. Its ability to bind phosphate may allow it to acquire phosphate from its host ; Belongs to the PstS family. | 0.996 |
phoU | relA | PA5365 | PA0934 | Phosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.616 |