node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA2548 | phoU | PA2548 | PA5365 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Phosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family. | 0.645 |
PA2548 | pstA | PA2548 | PA5367 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Membrane protein component of ABC phosphate transporter; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.978 |
PA2548 | pstB | PA2548 | PA5366 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | ATP-binding component of ABC phosphate transporter; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. | 0.967 |
PA2548 | pstC | PA2548 | PA5368 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Membrane protein component of ABC phosphate transporter; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.896 |
PA2548 | pstS | PA2548 | PA5369 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Phosphate ABC transporter, periplasmic phosphate-binding protein, PstS; Binds 1 inorganic phosphate per subunit with a KD of 0.34 uM. Required for phosphate transport. In strain PAO1 implicated in host cell adhesion; in some virulent strains (e.g. MDR25 which expresses very high levels of this protein) antibody fragments against this protein decrease host cell adhesion and increase transepithelial resistance of human epithelial cell monolayers. Its ability to bind phosphate may allow it to acquire phosphate from its host ; Belongs to the PstS family. | 0.925 |
PA2797 | pstB | PA2797 | PA5366 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | ATP-binding component of ABC phosphate transporter; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. | 0.808 |
phnE | phoA2 | PA3382 | PA0688 | Phosphonate transport protein PhnE; Product name confidence: Class 2 (High similarity to functionally studied protein). | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | 0.562 |
phnE | phoU | PA3382 | PA5365 | Phosphonate transport protein PhnE; Product name confidence: Class 2 (High similarity to functionally studied protein). | Phosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family. | 0.781 |
phnE | pstA | PA3382 | PA5367 | Phosphonate transport protein PhnE; Product name confidence: Class 2 (High similarity to functionally studied protein). | Membrane protein component of ABC phosphate transporter; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.758 |
phnE | pstB | PA3382 | PA5366 | Phosphonate transport protein PhnE; Product name confidence: Class 2 (High similarity to functionally studied protein). | ATP-binding component of ABC phosphate transporter; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. | 0.798 |
phnE | pstC | PA3382 | PA5368 | Phosphonate transport protein PhnE; Product name confidence: Class 2 (High similarity to functionally studied protein). | Membrane protein component of ABC phosphate transporter; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.740 |
phnE | pstS | PA3382 | PA5369 | Phosphonate transport protein PhnE; Product name confidence: Class 2 (High similarity to functionally studied protein). | Phosphate ABC transporter, periplasmic phosphate-binding protein, PstS; Binds 1 inorganic phosphate per subunit with a KD of 0.34 uM. Required for phosphate transport. In strain PAO1 implicated in host cell adhesion; in some virulent strains (e.g. MDR25 which expresses very high levels of this protein) antibody fragments against this protein decrease host cell adhesion and increase transepithelial resistance of human epithelial cell monolayers. Its ability to bind phosphate may allow it to acquire phosphate from its host ; Belongs to the PstS family. | 0.727 |
phoA2 | phnE | PA0688 | PA3382 | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | Phosphonate transport protein PhnE; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.562 |
phoA2 | phoB | PA0688 | PA5360 | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | Two-component response regulator PhoB; This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited. | 0.891 |
phoA2 | phoR | PA0688 | PA5361 | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | Two-component sensor PhoR; Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals. | 0.895 |
phoA2 | phoU | PA0688 | PA5365 | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | Phosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family. | 0.928 |
phoA2 | pstA | PA0688 | PA5367 | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | Membrane protein component of ABC phosphate transporter; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.976 |
phoA2 | pstB | PA0688 | PA5366 | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | ATP-binding component of ABC phosphate transporter; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. | 0.961 |
phoA2 | pstC | PA0688 | PA5368 | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | Membrane protein component of ABC phosphate transporter; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.899 |
phoB | phoA2 | PA5360 | PA0688 | Two-component response regulator PhoB; This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited. | Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. | 0.891 |