node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA0399 | PA0851 | PA0399 | PA0851 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | 0.926 |
PA0399 | PA4960 | PA0399 | PA4960 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Probable phosphoserine phosphatase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.947 |
PA0399 | cysE | PA0399 | PA3816 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | O-acetylserine synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.951 |
PA0399 | glyA1 | PA0399 | PA5415 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
PA0399 | glyA2 | PA0399 | PA2444 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
PA0399 | glyA3 | PA0399 | PA4602 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
PA0399 | ilvA1 | PA0399 | PA0331 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.926 |
PA0399 | ilvA2 | PA0399 | PA1326 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.926 |
PA0399 | sdaB | PA0399 | PA5379 | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | L-serine dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.914 |
PA0851 | PA0399 | PA0851 | PA0399 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.926 |
PA0851 | PA4960 | PA0851 | PA4960 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Probable phosphoserine phosphatase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.909 |
PA0851 | cysE | PA0851 | PA3816 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | O-acetylserine synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.807 |
PA0851 | dsdA | PA0851 | PA3357 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | D-serine dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the serine/threonine dehydratase family. DsdA subfamily. | 0.906 |
PA0851 | glyA1 | PA0851 | PA5415 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.906 |
PA0851 | glyA2 | PA0851 | PA2444 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.906 |
PA0851 | glyA3 | PA0851 | PA4602 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.906 |
PA0851 | ilvA1 | PA0851 | PA0331 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.923 |
PA0851 | ilvA2 | PA0851 | PA1326 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.922 |
PA0851 | sdaB | PA0851 | PA5379 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | L-serine dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.919 |
PA4960 | PA0399 | PA4960 | PA0399 | Probable phosphoserine phosphatase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Cystathionine beta-synthase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.947 |