STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (323 aa)    
Predicted Functional Partners:
wbpW
Phosphomannose isomerase/GDP-mannose WbpW; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the mannose-6-phosphate isomerase type 2 family.
 
 
 0.998
rmd
Oxidoreductase Rmd; Reductase that catalyzes the conversion of GDP-6-deoxy-D- mannose to GDP-4-dehydro-6-deoxy-D-mannose (GDP-D-rhamnose).
 
0.996
pslB
PslB; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa; Belongs to the mannose-6-phosphate isomerase type 2 family.
 
 
 0.980
algA
Phosphomannose isomerase / guanosine 5'-diphospho-D-mannose pyrophosphorylase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics; Belongs to the mannose-6-phosphate isomerase type 2 family.
 
 
 0.977
wbpX
Glycosyltransferase WbpX; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.971
pslA
PslA; Class 1: Function experimentally demonstrated in P. aeruginosa.
 
  
 0.968
wbpY
Glycosyltransferase WbpY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.959
wzt
ABC subunit of A-band LPS efflux transporter; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.955
wbpZ
Glycosyltransferase WbpZ; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.953
algD
GDP-mannose 6-dehydrogenase AlgD; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics.
 
 
 0.936
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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