STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadKConserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (277 aa)    
Predicted Functional Partners:
SMU_1043c
Putative phosphotransacetylase; Best Blastp Hit: sp|P39646|PTA_BACSU PROBABLE PHOSPHATE ACETYLTRANSFERASE (PHOSPHOTRANSACETYLASE) (VEGETATIVE PROTEIN 43) (VEG43) >gi|2126977|pir||S39743 phosphotransacetylase pta - Bacillus subtilis >gi|580883|emb|CAA51644.1| (X73124) ipa-88d [Bacillus subtilis] >gi|2636302|emb|CAB15793.1| (Z99123) phosphotransacetylase [Bacillus subtilis].
     
 0.948
nadD
Putative nicotinate mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
 
 0.933
nadE
NAD(+) synthetase (nitrogen-regulatory protein); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.931
SMU_1046c
Putative GTP pyrophosphokinase; Best Blastp Hit: dbj|BAB06568.1| (AP001516) GTP pyrophosphokinase [Bacillus halodurans].
  
    0.825
SMU_1044c
Putative pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.
  
  
 0.809
SMU_1048
Best Blastp Hit: pir||C69844 hypothetical protein yjbK - Bacillus subtilis >gi|2633512|emb|CAB13015.1| (Z99110) yjbK [Bacillus subtilis].
 
     0.537
SMU_583
Putative hemolysin; Best Blastp Hit: dbj|BAB06497.1| (AP001516) hemolysin-like protein [Bacillus halodurans].
  
  
 0.521
krpS
Putative phosphoribosylpyrophosphate synthetase, PRPP synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
 
   0.450
SMU_447
Best Blastp Hit: pir||E69894 hypothetical protein ynzC - Bacillus subtilis >gi|2634172|emb|CAB13672.1| (Z99113) ynzC [Bacillus subtilis].
  
     0.427
comF
Putative late competence protein; Best Blastp Hit: sp|P39145|CMF1_BACSU COMF OPERON PROTEIN 1 >gi|2127092|pir||I40387 hypothetical protein F1 - Bacillus subtilis >gi|7430372|pir||G69602 late competence protein required for DNA uptake comFA - Bacillus subtilis >gi|580841|emb|CAA79226.1| (Z18629) F1 [Bacillus subtilis] >gi|1762332|gb|AAC44940.1| (U56901) involved in transformation [Bacillus subtilis] >gi|2636073|emb|CAB15564.1| (Z99122) late competence protein [Bacillus subtilis].
  
     0.423
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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