STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fthSPutative formyl-tetrahydrofolate synthetase; Best Blastp Hit: sp|Q59925|FTHS_STRMU FORMATE--TETRAHYDROFOLATE LIGASE (FORMYLTETRAHYDROFOLATE SYNTHETASE) (FHS) (FTHFS) >gi|1103865|gb|AAB49329.1| (U39612) formyl-tetrahydrofolate synthetase [Streptococcus mutans]. (556 aa)    
Predicted Functional Partners:
folD
Putative tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 
 0.999
purH
Best Blastp Hit: dbj|BAB04352.1| (AP001509) phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Bacillus halodurans].
  
 0.982
glyA
Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.965
purN
Putative phosphoribosylglycinamide formyltransferase (GART); Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 0.965
purL
Putative phosphoribosylformylglycinamidine synthase, (FGAM synthase); Best Blastp Hit: pir||C69492 phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) component II - Archaeoglobus fulgidus >gi|2648599|gb|AAB89311.1| (AE000969) phosphoribosylformylglycinamidine synthase II (purL) [Archaeoglobus fulgidus].
  
 
 0.946
SMU_874
Conserved hypothetical protein; Best Blastp Hit: dbj|BAB05348.1| (AP001512) unknown conserved protein [Bacillus halodurans].
  
 
 0.946
dfrA
Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
  
 
 0.929
dfp
Putative DNA/pantothenate metabolism flavoprotein; Catalyzes the decarboxylation of 4'- phosphopantothenoylcysteine to 4'-phosphopantetheine; Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.
  
  
 0.883
metB
Putative cystathionine gamma-synthase; Best Blastp Hit: pir||G64047 cystathionine gamma-lyase homolog - Haemophilus influenzae (strain Rd KW20) >gi|1573037|gb|AAC21764.1| (U32694) cystathionine gamma-synthase (metB) [Haemophilus influenzae Rd] 4.4.1.1 cystathionine gamma-lyase or cystathionine beta-lyases 4.4.8.1.
   
  
 0.793
purC
Best Blastp Hit: sp|Q07296|PUR7_STRPN PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR SYNTHETASE) >gi|625868|pir||A36941 phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC 6.3.2.6) - Streptococcus pneumoniae >gi|295192|gb|AAA03540.1| (L15190) SAICAR synthetase [Streptococcus pneumoniae] >gi|663281|gb|AAA69512.1| (M36180) SAICAR synthetase [Streptococcus pneumoniae].
  
 
 0.791
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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