STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mtlA2PTS system, mannitol-specific enzyme IIA; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport. (145 aa)    
Predicted Functional Partners:
mtlD
Best Blastp Hit: sp|Q02418|MTLD_STRMU MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE >gi|282315|pir||C44798 mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17) mtlD - Streptococcus mutans >gi|153746|gb|AAA26942.1| (AF210133) mannitol-phosphate dehydrogenase [Streptococcus mutans].
 
 0.999
mtlA1
PTS system, mannitol-specific enzyme IIBC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.
 
 0.999
mtlR
Putative transcriptional regulator, antiterminator; Not necessary for mannitol utilization. May be involved in regulation of the mannitol phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).
 
  
 0.985
ptsH
Phosphoenolpyruvate:sugar phosphotransferase system HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
  
 0.973
fruI
Best Blastp Hit: dbj|BAB04547.1| (AP001510) PTS system, fructose-specific enzyme II, BC component [Bacillus halodurans].
 
  
 0.972
fruC
Best Blastp Hit: dbj|BAB04547.1| (AP001510) PTS system, fructose-specific enzyme II, BC component [Bacillus halodurans].
 
  
 0.961
celR
Best Blastp Hit: sp|P46321|CELR_BACSU PUTATIVE CEL OPERON REGULATOR >gi|1361400|pir||S57758 probable cel operon regulator - Bacillus subtilis >gi|7475600|pir||H69651 lichenan operon transcription antiterminator licR - Bacillus subtilis >gi|895747|emb|CAA90284.1| (Z49992) putative cel operon regulator [Bacillus subtilis] >gi|1783265|dbj|BAA11742.1| (D83026) cel operon regulator [Bacillus subtilis] >gi|2636395|emb|CAB15886.1| (Z99123) transcriptional regulator (antiterminator) [Bacillus subtilis].
 
  
 0.944
ptxB
Putative PTS system, enzyme IIB component; Best Blastp Hit: sp|P39302|PTXB_ECOLI UNKNOWN PENTITOL PHOSPHOTRANSFERASE ENZYME II, B COMPONENT >gi|1361123|pir||S56419 hypothetical 10.9K protein (aidB-rpsF intergenic region) - Escherichia coli## >gi|537035|gb|AAA97090.1| (U14003) ORF_o101 [Escherichia coli] >gi|1790638|gb|AAC77151.1| (AE000491) orf, hypothetical protein [Escherichia coli].
  
  
 0.819
ptxA
Putative PTS system, enzyme IIA component; Best Blastp Hit: sp|P39303|PTXA_ECOLI UNKNOWN PENTITOL PHOSPHOTRANSFERASE ENZYME II, A COMPONENT >gi|7429580|pir||F65230 hypothetical phosphotransferase enzyme II - Escherichia coli (strain K-12) >gi|2367359|gb|AAC77152.1| (AE000491) putative PTS system enzyme II A component [Escherichia coli].
 
  
 0.811
ptsI
Phosphoenolpyruvate:sugar phosphotransferase system enzyme I, PTS system EI component; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
     
 0.758
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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