STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (337 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase; Best Blastp Hit: gb|AAD33517.1|AF132127_2 (AF132127) glucose-6-phosphate isomerase [Streptococcus mutans].
  
 0.993
fbaA
Best Blastp Hit: dbj|BAB16889.1| (AB050113) class-II aldolase [Streptococcus bovis].
 
 
 0.978
pykF
Pyruvate kinase; Best Blastp Hit: gb|AAF25804.1|AF172173_2 (AF172173) pyruvate kinase [Streptococcus thermophilus].
 
 
 0.974
eno
Putative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity). Binds plasminogen and human salivary mucin MG2 when expressed on the bacterial cell surface, potentially allowing the bacterium to acquire surface-associated proteolytic activity that may help the dissemination through oral tissues and entrance into the blood stream; Belongs to the enolase family.
  
  
 0.955
manA
Best Blastp Hit: sp|Q59935|MANA_STRMU MANNOSE-6-PHOSPHATE ISOMERASE (PHOSPHOMANNOSE ISOMERASE) (PMI) (PHOSPHOHEXOMUTASE) >gi|451216|dbj|BAA04021.1| (D16594) Mannosephosphate Isomerase [Streptococcus mutans].
  
 
 0.951
pfkB
Putative fructose-1-phosphate kinase; Best Blastp Hit: sp|O31714|K1PF_BACSU 1-PHOSPHOFRUCTOKINASE (FRUCTOSE 1-PHOSPHATE KINASE) >gi|7434216|pir||A69627 fructose 1-phosphate kinase fruB - Bacillus subtilis >gi|2633810|emb|CAB13312.1| (Z99111) fructose-1-phosphate kinase [Bacillus subtilis] >gi|3282124|gb|AAC24914.1| (AF012285) fructose-1-phosphate kinase [Bacillus subtilis]; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
   
 
 0.947
scrK
Putative fructokinase; Best Blastp Hit: sp|Q07211|SCRK_STRMU FRUCTOKINASE >gi|287459|dbj|BAA02467.1| (D13175) fructokinase [Streptococcus mutans].
  
 
 0.945
lacB
Best Blastp Hit: pir||D43258 galactose-6-phosphate isomerase subunit LacB - Streptococcus mutans.
  
 
 0.940
lacA
Best Blastp Hit: sp|P26423|LACA_STRMU GALACTOSE-6-PHOSPHATE ISOMERASE LACA SUBUNIT >gi|322117|pir||C43258 galactoside O-acetyltransferase (EC 2.3.1.18) - Streptococcus mutans >gi|153673|gb|AAA26904.1| (M80797) galactosidase acetyltransferase [Streptococcus mutans].
  
 
 0.940
tkt
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
  
 
 0.940
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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