STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvEBest Blastp Hit: gb|AAF34406.1|AF164204_1 (AF164204) branched-chain amino acid aminotransferase [Lactococcus lactis subsp. cremoris] >gi|7620382|gb|AAF64593.1|AF169649_1 (AF169649) branched-chain aminotransferase IlvE [Lactococcus lactis]. (341 aa)    
Predicted Functional Partners:
ilvD
Best Blastp Hit: sp|P74689|ILVD_SYNY3 DIHYDROXY-ACID DEHYDRATASE (DAD) >gi|7436855|pir||S76895 hypothetical protein - Synechocystis sp. (strain PCC 6803) >gi|1653897|dbj|BAA18807.1| (D90917) dihydroxyacid dehydratase [Synechocystis sp.]; Belongs to the IlvD/Edd family.
  
 0.995
leuA
Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 0.988
metB
Putative cystathionine gamma-synthase; Best Blastp Hit: pir||G64047 cystathionine gamma-lyase homolog - Haemophilus influenzae (strain Rd KW20) >gi|1573037|gb|AAC21764.1| (U32694) cystathionine gamma-synthase (metB) [Haemophilus influenzae Rd] 4.4.1.1 cystathionine gamma-lyase or cystathionine beta-lyases 4.4.8.1.
   
 0.927
yfbQ
Putative aminotransferase; Best Blastp Hit: sp|P71348|YFBQ_HAEIN PROBABLE AMINOTRANSFERASE HI0286 >gi|1573250|gb|AAC21948.1| (U32714) aminotransferase## [Haemophilus influenzae Rd].
  
 
 0.911
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.908
gshAB
Putative glutamate-cysteine ligase; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.
     
 0.907
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.905
SMU_965
Best Blastp Hit: sp|P52985|DHOM_LACLA HOMOSERINE DEHYDROGENASE (HDH) >gi|2117450|pir||JC6049 homoserine dehydrogenase (EC 1.1.1.3) - Lactococcus lactis >gi|1255939|emb|CAA65713.1| (X96988) hom [Lactococcus lactis].
  
 
 0.896
ldh
Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 0.870
pfl
Pyruvate formate-lyase; Best Blastp Hit: sp|Q59934|PFL_STRMU FORMATE ACETYLTRANSFERASE (PYRUVATE FORMATE-LYASE) >gi|1129082|dbj|BAA09085.1| (D50491) Pyruvate formate-lyase [Streptococcus mutans].
   
 
  0.803
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
Server load: low (26%) [HD]