node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SMU_965 | ilvA | SMU_965 | SMU_234 | Best Blastp Hit: sp|P52985|DHOM_LACLA HOMOSERINE DEHYDROGENASE (HDH) >gi|2117450|pir||JC6049 homoserine dehydrogenase (EC 1.1.1.3) - Lactococcus lactis >gi|1255939|emb|CAA65713.1| (X96988) hom [Lactococcus lactis]. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.483 |
SMU_965 | ilvD | SMU_965 | SMU_2128 | Best Blastp Hit: sp|P52985|DHOM_LACLA HOMOSERINE DEHYDROGENASE (HDH) >gi|2117450|pir||JC6049 homoserine dehydrogenase (EC 1.1.1.3) - Lactococcus lactis >gi|1255939|emb|CAA65713.1| (X96988) hom [Lactococcus lactis]. | Best Blastp Hit: sp|P74689|ILVD_SYNY3 DIHYDROXY-ACID DEHYDRATASE (DAD) >gi|7436855|pir||S76895 hypothetical protein - Synechocystis sp. (strain PCC 6803) >gi|1653897|dbj|BAA18807.1| (D90917) dihydroxyacid dehydratase [Synechocystis sp.]; Belongs to the IlvD/Edd family. | 0.416 |
SMU_965 | ilvE | SMU_965 | SMU_1203 | Best Blastp Hit: sp|P52985|DHOM_LACLA HOMOSERINE DEHYDROGENASE (HDH) >gi|2117450|pir||JC6049 homoserine dehydrogenase (EC 1.1.1.3) - Lactococcus lactis >gi|1255939|emb|CAA65713.1| (X96988) hom [Lactococcus lactis]. | Best Blastp Hit: gb|AAF34406.1|AF164204_1 (AF164204) branched-chain amino acid aminotransferase [Lactococcus lactis subsp. cremoris] >gi|7620382|gb|AAF64593.1|AF169649_1 (AF169649) branched-chain aminotransferase IlvE [Lactococcus lactis]. | 0.896 |
SMU_965 | leuA | SMU_965 | SMU_1384 | Best Blastp Hit: sp|P52985|DHOM_LACLA HOMOSERINE DEHYDROGENASE (HDH) >gi|2117450|pir||JC6049 homoserine dehydrogenase (EC 1.1.1.3) - Lactococcus lactis >gi|1255939|emb|CAA65713.1| (X96988) hom [Lactococcus lactis]. | Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.483 |
SMU_965 | metB | SMU_965 | SMU_1675 | Best Blastp Hit: sp|P52985|DHOM_LACLA HOMOSERINE DEHYDROGENASE (HDH) >gi|2117450|pir||JC6049 homoserine dehydrogenase (EC 1.1.1.3) - Lactococcus lactis >gi|1255939|emb|CAA65713.1| (X96988) hom [Lactococcus lactis]. | Putative cystathionine gamma-synthase; Best Blastp Hit: pir||G64047 cystathionine gamma-lyase homolog - Haemophilus influenzae (strain Rd KW20) >gi|1573037|gb|AAC21764.1| (U32694) cystathionine gamma-synthase (metB) [Haemophilus influenzae Rd] 4.4.1.1 cystathionine gamma-lyase or cystathionine beta-lyases 4.4.8.1. | 0.893 |
SMU_965 | thrB | SMU_965 | SMU_966 | Best Blastp Hit: sp|P52985|DHOM_LACLA HOMOSERINE DEHYDROGENASE (HDH) >gi|2117450|pir||JC6049 homoserine dehydrogenase (EC 1.1.1.3) - Lactococcus lactis >gi|1255939|emb|CAA65713.1| (X96988) hom [Lactococcus lactis]. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.999 |
gshAB | ilvE | SMU_267c | SMU_1203 | Putative glutamate-cysteine ligase; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine. | Best Blastp Hit: gb|AAF34406.1|AF164204_1 (AF164204) branched-chain amino acid aminotransferase [Lactococcus lactis subsp. cremoris] >gi|7620382|gb|AAF64593.1|AF169649_1 (AF169649) branched-chain aminotransferase IlvE [Lactococcus lactis]. | 0.907 |
gshAB | metB | SMU_267c | SMU_1675 | Putative glutamate-cysteine ligase; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine. | Putative cystathionine gamma-synthase; Best Blastp Hit: pir||G64047 cystathionine gamma-lyase homolog - Haemophilus influenzae (strain Rd KW20) >gi|1573037|gb|AAC21764.1| (U32694) cystathionine gamma-synthase (metB) [Haemophilus influenzae Rd] 4.4.1.1 cystathionine gamma-lyase or cystathionine beta-lyases 4.4.8.1. | 0.415 |
ilvA | SMU_965 | SMU_234 | SMU_965 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Best Blastp Hit: sp|P52985|DHOM_LACLA HOMOSERINE DEHYDROGENASE (HDH) >gi|2117450|pir||JC6049 homoserine dehydrogenase (EC 1.1.1.3) - Lactococcus lactis >gi|1255939|emb|CAA65713.1| (X96988) hom [Lactococcus lactis]. | 0.483 |
ilvA | ilvD | SMU_234 | SMU_2128 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Best Blastp Hit: sp|P74689|ILVD_SYNY3 DIHYDROXY-ACID DEHYDRATASE (DAD) >gi|7436855|pir||S76895 hypothetical protein - Synechocystis sp. (strain PCC 6803) >gi|1653897|dbj|BAA18807.1| (D90917) dihydroxyacid dehydratase [Synechocystis sp.]; Belongs to the IlvD/Edd family. | 0.917 |
ilvA | ilvE | SMU_234 | SMU_1203 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Best Blastp Hit: gb|AAF34406.1|AF164204_1 (AF164204) branched-chain amino acid aminotransferase [Lactococcus lactis subsp. cremoris] >gi|7620382|gb|AAF64593.1|AF169649_1 (AF169649) branched-chain aminotransferase IlvE [Lactococcus lactis]. | 0.905 |
ilvA | ldh | SMU_234 | SMU_1115 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.838 |
ilvA | metB | SMU_234 | SMU_1675 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Putative cystathionine gamma-synthase; Best Blastp Hit: pir||G64047 cystathionine gamma-lyase homolog - Haemophilus influenzae (strain Rd KW20) >gi|1573037|gb|AAC21764.1| (U32694) cystathionine gamma-synthase (metB) [Haemophilus influenzae Rd] 4.4.1.1 cystathionine gamma-lyase or cystathionine beta-lyases 4.4.8.1. | 0.866 |
ilvA | pfl | SMU_234 | SMU_402 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Pyruvate formate-lyase; Best Blastp Hit: sp|Q59934|PFL_STRMU FORMATE ACETYLTRANSFERASE (PYRUVATE FORMATE-LYASE) >gi|1129082|dbj|BAA09085.1| (D50491) Pyruvate formate-lyase [Streptococcus mutans]. | 0.824 |
ilvA | thrB | SMU_234 | SMU_966 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.426 |
ilvD | SMU_965 | SMU_2128 | SMU_965 | Best Blastp Hit: sp|P74689|ILVD_SYNY3 DIHYDROXY-ACID DEHYDRATASE (DAD) >gi|7436855|pir||S76895 hypothetical protein - Synechocystis sp. (strain PCC 6803) >gi|1653897|dbj|BAA18807.1| (D90917) dihydroxyacid dehydratase [Synechocystis sp.]; Belongs to the IlvD/Edd family. | Best Blastp Hit: sp|P52985|DHOM_LACLA HOMOSERINE DEHYDROGENASE (HDH) >gi|2117450|pir||JC6049 homoserine dehydrogenase (EC 1.1.1.3) - Lactococcus lactis >gi|1255939|emb|CAA65713.1| (X96988) hom [Lactococcus lactis]. | 0.416 |
ilvD | ilvA | SMU_2128 | SMU_234 | Best Blastp Hit: sp|P74689|ILVD_SYNY3 DIHYDROXY-ACID DEHYDRATASE (DAD) >gi|7436855|pir||S76895 hypothetical protein - Synechocystis sp. (strain PCC 6803) >gi|1653897|dbj|BAA18807.1| (D90917) dihydroxyacid dehydratase [Synechocystis sp.]; Belongs to the IlvD/Edd family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.917 |
ilvD | ilvE | SMU_2128 | SMU_1203 | Best Blastp Hit: sp|P74689|ILVD_SYNY3 DIHYDROXY-ACID DEHYDRATASE (DAD) >gi|7436855|pir||S76895 hypothetical protein - Synechocystis sp. (strain PCC 6803) >gi|1653897|dbj|BAA18807.1| (D90917) dihydroxyacid dehydratase [Synechocystis sp.]; Belongs to the IlvD/Edd family. | Best Blastp Hit: gb|AAF34406.1|AF164204_1 (AF164204) branched-chain amino acid aminotransferase [Lactococcus lactis subsp. cremoris] >gi|7620382|gb|AAF64593.1|AF169649_1 (AF169649) branched-chain aminotransferase IlvE [Lactococcus lactis]. | 0.995 |
ilvD | leuA | SMU_2128 | SMU_1384 | Best Blastp Hit: sp|P74689|ILVD_SYNY3 DIHYDROXY-ACID DEHYDRATASE (DAD) >gi|7436855|pir||S76895 hypothetical protein - Synechocystis sp. (strain PCC 6803) >gi|1653897|dbj|BAA18807.1| (D90917) dihydroxyacid dehydratase [Synechocystis sp.]; Belongs to the IlvD/Edd family. | Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.994 |
ilvD | thrB | SMU_2128 | SMU_966 | Best Blastp Hit: sp|P74689|ILVD_SYNY3 DIHYDROXY-ACID DEHYDRATASE (DAD) >gi|7436855|pir||S76895 hypothetical protein - Synechocystis sp. (strain PCC 6803) >gi|1653897|dbj|BAA18807.1| (D90917) dihydroxyacid dehydratase [Synechocystis sp.]; Belongs to the IlvD/Edd family. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.752 |