STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
plsYConserved hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (212 aa)    
Predicted Functional Partners:
plsX
Putative fatty acid/phospholipid synthesis protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
 
  
 0.996
gpsA
Best Blastp Hit: sp|P46919|GPDA_BACSU GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(P)+] (NAD(P)H-DEPENDENT DIHYDROXYACETONE-PHOSPHATE REDUCTASE) >gi|974332|gb|AAA86746.1| (U32164) NAD(P)H-dependent dihydroxyacetone-phosphate reductase [Bacillus subtilis]; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
 
 
 0.947
SMU_624
Best Blastp Hit: pir||E69826 probable 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) yhdO - Bacillus subtilis >gi|2226210|emb|CAA74499.1| (Y14082) hypothetical protein [Bacillus subtilis] >gi|2633289|emb|CAB12793.1| (Z99109) similar to 1-acylglycerol-3-phosphate O-acyltransferase [Bacillus subtilis].
  
 
 0.934
SMU_1327c
Best Blastp Hit: pir||E69820 conserved hypothetical protein yhbA - Bacillus subtilis >gi|1903044|emb|CAB07527.1| (Z93102) hypothetical 48.5 kd protein [Bacillus subtilis] >gi|2633214|emb|CAB12719.1| (Z99108) alternate gene name: ygaP similar to hypothetical proteins [Bacillus subtilis].
      
 0.629
SMU_694c
Putative ferredoxin (4Fe-4S); Best Blastp Hit: dbj|BAB06076.1| (AP001515) ferredoxin [4Fe-4S] [Bacillus halodurans].
      
 0.624
parE
Putative DNA topoisomerase IV, subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily.
     
 0.602
SMU_1209c
Hypothetical protein; Best Blastp Hit: gi|6715600 golgi autoantigen, golgin subfamily a, 4; golgin 245; golgin-240; p230 [Homo sapiens] >gi|1213484|gb|AAC50434.1| (U41740) trans-Golgi p230 [Homo sapiens] >gi|1589554|prf||2211333A peripheral membrane protein p230 [Homo sapiens].
       0.520
topA
Putative DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...]
     
 0.441
phoU
Putative phosphate transport system regulatory protein; Plays a role in the regulation of phosphate uptake.
     
 0.418
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.