STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMU_1228cConserved hypothetical protein, possible amidotransferase; Best Blastp Hit: gb|AAF13751.1|AF117351_8 (AF117351) unknown [Zymomonas mobilis]. (236 aa)    
Predicted Functional Partners:
guaB
Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.982
apt
Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.920
hprT
Best Blastp Hit: sp|Q02522|HPRT_LACLA HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRT) (HGPRTASE) >gi|418760|pir||S30100 hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) - Lactococcus lactis >gi|44026|emb|CAA48876.1| (X69123) hypoxanthine guanine phosphoribosyltransferase [Lactococcus lactis] >gi|49105|emb|CAA47404.1| (X67015) hypoxanthine phosphoribosyltransferase [Lactococcus lactis] >gi|384297|prf||1905381A hypoxanthine guanine phosphoribosyltransferase [Lactococcus lactis].
  
 
 0.916
kguA
Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.910
SMU_1717c
Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 
 0.905
guaA
Putative GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
 0.904
punA
Putative purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
     
 0.800
SMU_1230c
Conserved hypothetical protein; Best Blastp Hit: dbj|BAA94663.1| (D86934) ORF N043 [Staphylococcus aureus].
       0.767
purL
Putative phosphoribosylformylglycinamidine synthase, (FGAM synthase); Best Blastp Hit: pir||C69492 phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) component II - Archaeoglobus fulgidus >gi|2648599|gb|AAB89311.1| (AE000969) phosphoribosylformylglycinamidine synthase II (purL) [Archaeoglobus fulgidus].
  
  
 0.576
deoD
Best Blastp Hit: sp|O32810|DEOD_LACLC PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PHOSPHORYLASE) (PNP) >gi|2281310|gb|AAC45498.1| (U80410) purine nucleoside phosphorylase [Lactococcus lactis subsp. cremoris].
     
 0.512
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.