STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polCDNA polymerase III, alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1465 aa)    
Predicted Functional Partners:
dnaX
DNA polymerase III, gamma/tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
   
 0.981
dnaN
Putative DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for init [...]
   
 0.928
SMU_628
Conserved hypothetical protein; Best Blastp Hit: emb|CAA72898.1| (Y12224) hypothetical protein [Streptococcus agalactiae].
    
 0.925
holB
Best Blastp Hit: sp|P37540|HOLB_BACSU DNA POLYMERASE III, DELTA' SUBUNIT >gi|2126931|pir||S66061 DNA polymerase III delta' chain holB - Bacillus subtilis >gi|467421|dbj|BAA05267.1| (D26185) similar to B. subtilis DnaH [Bacillus subtilis] >gi|2632298|emb|CAB11807.1| (Z99104) DNA polymerase III (delta' subunit) [Bacillus subtilis].
   
 
 0.916
dnaE
DNA polymerase III, alpha chain; Best Blastp Hit: gb|AAF98350.1| (AF280766) DNA polymerase III alpha subunit [Streptococcus pyogenes].
    
0.915
polI
DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 
 0.778
trcF
Putative transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
  
  
 0.689
tmcAL
Conserved hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
  
    0.687
SMU_1798c
Conserved hypothetical protein; Best Blastp Hit: sp|P54456|YQEK_BACSU HYPOTHETICAL 21.3 KD PROTEIN IN AROD-COMER INTERGENIC REGION >gi|7429525|pir||G69951 conserved hypothetical protein yqeK - Bacillus subtilis >gi|1303792|dbj|BAA12448.1| (D84432) YqeK [Bacillus subtilis] >gi|2635009|emb|CAB14505.1| (Z99117) similar to hypothetical proteins [Bacillus subtilis].
  
     0.676
whiA
Conserved hypothetical protein; Involved in cell division and chromosome segregation.
  
     0.654
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.