node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SMU_1261c | hisA | SMU_1261c | SMU_1265 | Putative phosphoribosyl-ATP pyrophosphohydrolase; Best Blastp Hit: pir||D75482 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase - Deinococcus radiodurans (strain R1) >gi|6458442|gb|AAF10312.1|AE001929_5 (AE001929) phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase [Deinococcus radiodurans]. | Best Blastp Hit: gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus]. | 0.991 |
SMU_1261c | hisB | SMU_1261c | SMU_1268 | Putative phosphoribosyl-ATP pyrophosphohydrolase; Best Blastp Hit: pir||D75482 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase - Deinococcus radiodurans (strain R1) >gi|6458442|gb|AAF10312.1|AE001929_5 (AE001929) phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase [Deinococcus radiodurans]. | Best Blastp Hit: dbj|BAB07300.1| (AP001519) imidazoleglycerol-phosphate dehydratase [Bacillus halodurans]. | 0.987 |
SMU_1261c | hisC | SMU_1261c | SMU_1273 | Putative phosphoribosyl-ATP pyrophosphohydrolase; Best Blastp Hit: pir||D75482 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase - Deinococcus radiodurans (strain R1) >gi|6458442|gb|AAF10312.1|AE001929_5 (AE001929) phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase [Deinococcus radiodurans]. | Best Blastp Hit: sp|Q02135|HIS8_LACLA HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (IMIDAZOLE ACETOL-PHOSPHATE TRANSAMINASE) >gi|2565139|gb|AAB81901.1| (U92974) HisC [Lactococcus lactis]; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.913 |
SMU_1261c | hisD | SMU_1261c | SMU_1270 | Putative phosphoribosyl-ATP pyrophosphohydrolase; Best Blastp Hit: pir||D75482 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase - Deinococcus radiodurans (strain R1) >gi|6458442|gb|AAF10312.1|AE001929_5 (AE001929) phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase [Deinococcus radiodurans]. | Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.966 |
SMU_1261c | hisF | SMU_1261c | SMU_1264 | Putative phosphoribosyl-ATP pyrophosphohydrolase; Best Blastp Hit: pir||D75482 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase - Deinococcus radiodurans (strain R1) >gi|6458442|gb|AAF10312.1|AE001929_5 (AE001929) phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase [Deinococcus radiodurans]. | Putative imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.991 |
SMU_1261c | hisG | SMU_1261c | SMU_1271 | Putative phosphoribosyl-ATP pyrophosphohydrolase; Best Blastp Hit: pir||D75482 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase - Deinococcus radiodurans (strain R1) >gi|6458442|gb|AAF10312.1|AE001929_5 (AE001929) phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase [Deinococcus radiodurans]. | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.997 |
SMU_1261c | hisH | SMU_1261c | SMU_1266 | Putative phosphoribosyl-ATP pyrophosphohydrolase; Best Blastp Hit: pir||D75482 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase - Deinococcus radiodurans (strain R1) >gi|6458442|gb|AAF10312.1|AE001929_5 (AE001929) phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase [Deinococcus radiodurans]. | Putative glutamine amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.983 |
SMU_1261c | hisI | SMU_1261c | SMU_1263 | Putative phosphoribosyl-ATP pyrophosphohydrolase; Best Blastp Hit: pir||D75482 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase - Deinococcus radiodurans (strain R1) >gi|6458442|gb|AAF10312.1|AE001929_5 (AE001929) phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase [Deinococcus radiodurans]. | Putative phosphoribosyl-ATP pyrophosphatase / phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
SMU_1261c | hisZ | SMU_1261c | SMU_1272 | Putative phosphoribosyl-ATP pyrophosphohydrolase; Best Blastp Hit: pir||D75482 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase - Deinococcus radiodurans (strain R1) >gi|6458442|gb|AAF10312.1|AE001929_5 (AE001929) phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase [Deinococcus radiodurans]. | Putative histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.987 |
SMU_1261c | serB | SMU_1261c | SMU_1269 | Putative phosphoribosyl-ATP pyrophosphohydrolase; Best Blastp Hit: pir||D75482 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase - Deinococcus radiodurans (strain R1) >gi|6458442|gb|AAF10312.1|AE001929_5 (AE001929) phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase [Deinococcus radiodurans]. | Best Blastp Hit: pir||T36772 probable phosphoserine phosphatase - Streptomyces coelicolor >gi|5525060|emb|CAB50876.1| (AL096844) putative phosphoserine phosphatase [Streptomyces coelicolor A3(2)]. | 0.805 |
hisA | SMU_1261c | SMU_1265 | SMU_1261c | Best Blastp Hit: gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus]. | Putative phosphoribosyl-ATP pyrophosphohydrolase; Best Blastp Hit: pir||D75482 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase - Deinococcus radiodurans (strain R1) >gi|6458442|gb|AAF10312.1|AE001929_5 (AE001929) phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase [Deinococcus radiodurans]. | 0.991 |
hisA | hisB | SMU_1265 | SMU_1268 | Best Blastp Hit: gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus]. | Best Blastp Hit: dbj|BAB07300.1| (AP001519) imidazoleglycerol-phosphate dehydratase [Bacillus halodurans]. | 0.998 |
hisA | hisC | SMU_1265 | SMU_1273 | Best Blastp Hit: gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus]. | Best Blastp Hit: sp|Q02135|HIS8_LACLA HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (IMIDAZOLE ACETOL-PHOSPHATE TRANSAMINASE) >gi|2565139|gb|AAB81901.1| (U92974) HisC [Lactococcus lactis]; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.996 |
hisA | hisD | SMU_1265 | SMU_1270 | Best Blastp Hit: gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus]. | Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisA | hisF | SMU_1265 | SMU_1264 | Best Blastp Hit: gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus]. | Putative imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | SMU_1265 | SMU_1271 | Best Blastp Hit: gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus]. | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.996 |
hisA | hisH | SMU_1265 | SMU_1266 | Best Blastp Hit: gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus]. | Putative glutamine amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | SMU_1265 | SMU_1263 | Best Blastp Hit: gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus]. | Putative phosphoribosyl-ATP pyrophosphatase / phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | SMU_1265 | SMU_1272 | Best Blastp Hit: gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus]. | Putative histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.987 |
hisA | serB | SMU_1265 | SMU_1269 | Best Blastp Hit: gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus]. | Best Blastp Hit: pir||T36772 probable phosphoserine phosphatase - Streptomyces coelicolor >gi|5525060|emb|CAB50876.1| (AL096844) putative phosphoserine phosphatase [Streptomyces coelicolor A3(2)]. | 0.912 |