STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lacG6-phospho-beta-galactosidase; Best Blastp Hit: sp|P50978|LACG_STRMU 6-PHOSPHO-BETA-GALACTOSIDASE (BETA-D-PHOSPHOGALACTOSIDE GALACTOHYDROLASE) (PGALASE) (P-BETA-GAL) (PBG) >gi|433810|gb|AAA16450.1| (L18993) phospho-beta-galactosidase [Streptococcus mutans]; Belongs to the glycosyl hydrolase 1 family. (468 aa)    
Predicted Functional Partners:
lacE
PTS system, lactose-specific enzyme IIBC EIIBC-LAC); The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II LacEF PTS system is involved in lactose transport.
 
 
 0.999
lacF
PTS system, lactose-specific enzyme IIA EIIA-LAC); The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II LacEF PTS system is involved in lactose transport.
 
 
 0.999
lacB
Best Blastp Hit: pir||D43258 galactose-6-phosphate isomerase subunit LacB - Streptococcus mutans.
 
 
 0.998
lacA
Best Blastp Hit: sp|P26423|LACA_STRMU GALACTOSE-6-PHOSPHATE ISOMERASE LACA SUBUNIT >gi|322117|pir||C43258 galactoside O-acetyltransferase (EC 2.3.1.18) - Streptococcus mutans >gi|153673|gb|AAA26904.1| (M80797) galactosidase acetyltransferase [Streptococcus mutans].
 
 
 0.993
lacD
Tagatose-1,6-bisphosphate aldolase; Best Blastp Hit: sp|P26425|LACD_STRMU TAGATOSE 1,6-DIPHOSPHATE ALDOLASE (TAGATOSE-BISPHOSPHATE ALDOLASE) (D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE) >gi|322120|pir||F43258 tagatose-1,6-bisphosphate aldolase homolog LacD - Streptococcus mutans >gi|153676|gb|AAA26907.1| (M80797) tagatose 1,6-aldolase [Streptococcus mutans].
 
  
 0.992
lacC
Tagatose-6-phosphate kinase; Best Blastp Hit: sp|P26421|LACC_STRMU TAGATOSE-6-PHOSPHATE KINASE (PHOSPHOTAGATOKINASE) >gi|322119|pir||E43258 tagatose-6-phosphate kinase - Streptococcus mutans >gi|153675|gb|AAA26906.1| (M80797) tagatose 6-P kinase [Streptococcus mutans]; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
  
  
 0.979
lacR
Lactose repressor; Repressor of the lactose catabolism operon. Galactose-6- phosphate is the inducer.
 
  
 0.845
manA
Best Blastp Hit: sp|Q59935|MANA_STRMU MANNOSE-6-PHOSPHATE ISOMERASE (PHOSPHOMANNOSE ISOMERASE) (PMI) (PHOSPHOHEXOMUTASE) >gi|451216|dbj|BAA04021.1| (D16594) Mannosephosphate Isomerase [Streptococcus mutans].
 
  
 0.716
lacX
Best Blastp Hit: sp|P23496|LAXP_LACLA LACX PROTEIN, PLASMID >gi|97946|pir||D23696 lacX protein - Lactococcus lactis >gi|149413|gb|AAA25184.1| (M60447) ORF [Lactococcus lactis].
  
  
 0.685
SMU_507
Putative transcriptional regulator (DeoR family); Best Blastp Hit: pir||C69632 transcription repressor glcR - Bacillus subtilis >gi|1763710|emb|CAB05951.1| (Z83337) highly similar to phosphotransferase system regulator [Bacillus subtilis] >gi|2636155|emb|CAB15647.1| (Z99122) transcriptional regulator (DeoR family) [Bacillus subtilis].
     
 0.675
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.