STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lacFPTS system, lactose-specific enzyme IIA EIIA-LAC); The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II LacEF PTS system is involved in lactose transport. (104 aa)    
Predicted Functional Partners:
lacG
6-phospho-beta-galactosidase; Best Blastp Hit: sp|P50978|LACG_STRMU 6-PHOSPHO-BETA-GALACTOSIDASE (BETA-D-PHOSPHOGALACTOSIDE GALACTOHYDROLASE) (PGALASE) (P-BETA-GAL) (PBG) >gi|433810|gb|AAA16450.1| (L18993) phospho-beta-galactosidase [Streptococcus mutans]; Belongs to the glycosyl hydrolase 1 family.
 
 
 0.999
lacE
PTS system, lactose-specific enzyme IIBC EIIBC-LAC); The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II LacEF PTS system is involved in lactose transport.
 
 0.999
lacA
Best Blastp Hit: sp|P26423|LACA_STRMU GALACTOSE-6-PHOSPHATE ISOMERASE LACA SUBUNIT >gi|322117|pir||C43258 galactoside O-acetyltransferase (EC 2.3.1.18) - Streptococcus mutans >gi|153673|gb|AAA26904.1| (M80797) galactosidase acetyltransferase [Streptococcus mutans].
  
  
 0.989
lacC
Tagatose-6-phosphate kinase; Best Blastp Hit: sp|P26421|LACC_STRMU TAGATOSE-6-PHOSPHATE KINASE (PHOSPHOTAGATOKINASE) >gi|322119|pir||E43258 tagatose-6-phosphate kinase - Streptococcus mutans >gi|153675|gb|AAA26906.1| (M80797) tagatose 6-P kinase [Streptococcus mutans]; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
  
  
 0.975
lacD
Tagatose-1,6-bisphosphate aldolase; Best Blastp Hit: sp|P26425|LACD_STRMU TAGATOSE 1,6-DIPHOSPHATE ALDOLASE (TAGATOSE-BISPHOSPHATE ALDOLASE) (D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE) >gi|322120|pir||F43258 tagatose-1,6-bisphosphate aldolase homolog LacD - Streptococcus mutans >gi|153676|gb|AAA26907.1| (M80797) tagatose 1,6-aldolase [Streptococcus mutans].
  
  
 0.960
lacB
Best Blastp Hit: pir||D43258 galactose-6-phosphate isomerase subunit LacB - Streptococcus mutans.
  
  
 0.953
ptsH
Phosphoenolpyruvate:sugar phosphotransferase system HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
   
  0.943
ptcB
Best Blastp Hit: pir||D82219 PTS system, cellobiose-specific IIB component VC1281 [imported] - Vibrio cholerae (group O1 strain N16961) >gi|9655767|gb|AAF94440.1| (AE004207) PTS system, cellobiose-specific IIB component [Vibrio cholerae].
 
 
 0.934
ptcC
Putative PTS system, cellobiose-specific IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.
 
  
 0.892
SMU_177
Hypothetical protein; Best Blastp Hit: gi|7335665 cytochrome c oxidase subunit III [Echinococcus multilocularis] >gi|6138996|dbj|BAA84927.2| (AB018440) cytochrome oxidase subunit 3 [Echinococcus multilocularis].
 
  
 0.878
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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