STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pflAPyruvate-formate lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (263 aa)    
Predicted Functional Partners:
pfl
Pyruvate formate-lyase; Best Blastp Hit: sp|Q59934|PFL_STRMU FORMATE ACETYLTRANSFERASE (PYRUVATE FORMATE-LYASE) >gi|1129082|dbj|BAA09085.1| (D50491) Pyruvate formate-lyase [Streptococcus mutans].
 
  
 0.961
pfl2
Best Blastp Hit: sp|P75793|PFLF_ECOLI PUTATIVE FORMATE ACETYLTRANSFERASE 3 (PYRUVATE FORMATE-LYASE 3) >gi|7427871|pir||G64819 probable formate C-acetyltransferase (EC 2.3.1.54) - Escherichia coli >gi|1787044|gb|AAC73910.1| (AE000184) putative formate acetyltransferase [Escherichia coli] >gi|4062397|dbj|BAA35511.1| (D90720) Formate acetyltransferase 2 (EC 2.3.1.54) (pyruvate formate-lyase 2). [Escherichia coli].
 
  
 0.904
adhE
Best Blastp Hit: emb|CAA04467.1| (AJ001008) Alcohol-acetaldehyde dehydrogenase [Lactococcus lactis]; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
 
  
 0.854
hlyX
Putative hemolysin; Best Blastp Hit: gb|AAC05772.1| (AF051356) putative hemolysin [Streptococcus mutans].
  
    0.634
ahpC
Alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
   
  
 0.571
adhA
Putative acetoin dehydrogenase (TPP-dependent), E1 component alpha subunit; Best Blastp Hit: dbj|BAB04495.1| (AP001509) acetoin dehydrogenase (TPP-dependent) alpha chain [Bacillus halodurans].
   
  
 0.562
SMU_1694c
Putative permease; Best Blastp Hit: gb|AAC05771.1| (AF051356) putative permease [Streptococcus mutans].
       0.515
pdhC
Putative dihydrolipoamide acetyltransferase, E2 component; Best Blastp Hit: sp|O31550|ACOC_BACSU DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF ACETOIN CLEAVING SYSTEM (ACETOIN DEHYDROGENASE E2 COMPONENT) >gi|7433670|pir||F69581 acetoin dehydrogenase E2 component (dihydrolipoamide acetyltra) acoC - Bacillus subtilis >gi|2633132|emb|CAB12637.1| (Z99108) acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [Bacillus subtilis] >gi|2780393|dbj|BAA24294.1| (D78509) YfjI [Bacillus subtilis].
   
  
 0.507
adhD
Best Blastp Hit: pir||I40794 dihydrolipoamide dehydrogenase (EC 1.8.1.4) - Clostridium magnum >gi|472330|gb|AAA21748.1| (L31844) dihydrolipoamide dehydrogenase [Clostridium magnum].
   
  
 0.506
ldh
Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
   
  
 0.457
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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