node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SMU_1043c | comEB | SMU_1043c | SMU_1849 | Putative phosphotransacetylase; Best Blastp Hit: sp|P39646|PTA_BACSU PROBABLE PHOSPHATE ACETYLTRANSFERASE (PHOSPHOTRANSACETYLASE) (VEGETATIVE PROTEIN 43) (VEG43) >gi|2126977|pir||S39743 phosphotransacetylase pta - Bacillus subtilis >gi|580883|emb|CAA51644.1| (X73124) ipa-88d [Bacillus subtilis] >gi|2636302|emb|CAB15793.1| (Z99123) phosphotransacetylase [Bacillus subtilis]. | Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. | 0.556 |
SMU_325 | comEB | SMU_325 | SMU_1849 | Putative dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. | 0.942 |
SMU_325 | kitH | SMU_325 | SMU_1086 | Putative dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Putative thymidine kinase; Best Blastp Hit: sp|P47848|KITH_STRGC THYMIDINE KINASE >gi|703442|gb|AAB02289.1| (L40415) thymidine kinase [Streptococcus gordonii]. | 0.958 |
SMU_325 | kthY | SMU_325 | SMU_1663 | Putative dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.940 |
SMU_325 | thyA | SMU_325 | SMU_944 | Putative dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.960 |
cmk | comEB | SMU_696 | SMU_1849 | Putative cytidylate kinase; Best Blastp Hit: sp|P38493|KCY_BACSU CYTIDYLATE KINASE (CK) (CYTIDINE MONOPHOSPHATE KINASE) (CMP KINASE) >gi|7448348|pir||F69601 cytidylate kinase cmk - Bacillus subtilis >gi|533105|gb|AAA85149.1| (U11687) unknown [Bacillus subtilis] >gi|1146214|gb|AAC83961.1| (L47648) cytidine monophosphate kinase [Bacillus subtilis] >gi|2634707|emb|CAB14205.1| (Z99115) cytidylate kinase [Bacillus subtilis] >gi|2634724|emb|CAB14221.1| (Z99116) cytidylate kinase [Bacillus subtilis]. | Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. | 0.901 |
cmk | kitH | SMU_696 | SMU_1086 | Putative cytidylate kinase; Best Blastp Hit: sp|P38493|KCY_BACSU CYTIDYLATE KINASE (CK) (CYTIDINE MONOPHOSPHATE KINASE) (CMP KINASE) >gi|7448348|pir||F69601 cytidylate kinase cmk - Bacillus subtilis >gi|533105|gb|AAA85149.1| (U11687) unknown [Bacillus subtilis] >gi|1146214|gb|AAC83961.1| (L47648) cytidine monophosphate kinase [Bacillus subtilis] >gi|2634707|emb|CAB14205.1| (Z99115) cytidylate kinase [Bacillus subtilis] >gi|2634724|emb|CAB14221.1| (Z99116) cytidylate kinase [Bacillus subtilis]. | Putative thymidine kinase; Best Blastp Hit: sp|P47848|KITH_STRGC THYMIDINE KINASE >gi|703442|gb|AAB02289.1| (L40415) thymidine kinase [Streptococcus gordonii]. | 0.715 |
cmk | pyrG | SMU_696 | SMU_97 | Putative cytidylate kinase; Best Blastp Hit: sp|P38493|KCY_BACSU CYTIDYLATE KINASE (CK) (CYTIDINE MONOPHOSPHATE KINASE) (CMP KINASE) >gi|7448348|pir||F69601 cytidylate kinase cmk - Bacillus subtilis >gi|533105|gb|AAA85149.1| (U11687) unknown [Bacillus subtilis] >gi|1146214|gb|AAC83961.1| (L47648) cytidine monophosphate kinase [Bacillus subtilis] >gi|2634707|emb|CAB14205.1| (Z99115) cytidylate kinase [Bacillus subtilis] >gi|2634724|emb|CAB14221.1| (Z99116) cytidylate kinase [Bacillus subtilis]. | CTP synthetase (UTP-ammonia lyase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.424 |
comEB | SMU_1043c | SMU_1849 | SMU_1043c | Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. | Putative phosphotransacetylase; Best Blastp Hit: sp|P39646|PTA_BACSU PROBABLE PHOSPHATE ACETYLTRANSFERASE (PHOSPHOTRANSACETYLASE) (VEGETATIVE PROTEIN 43) (VEG43) >gi|2126977|pir||S39743 phosphotransacetylase pta - Bacillus subtilis >gi|580883|emb|CAA51644.1| (X73124) ipa-88d [Bacillus subtilis] >gi|2636302|emb|CAB15793.1| (Z99123) phosphotransacetylase [Bacillus subtilis]. | 0.556 |
comEB | SMU_325 | SMU_1849 | SMU_325 | Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. | Putative dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.942 |
comEB | cmk | SMU_1849 | SMU_696 | Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. | Putative cytidylate kinase; Best Blastp Hit: sp|P38493|KCY_BACSU CYTIDYLATE KINASE (CK) (CYTIDINE MONOPHOSPHATE KINASE) (CMP KINASE) >gi|7448348|pir||F69601 cytidylate kinase cmk - Bacillus subtilis >gi|533105|gb|AAA85149.1| (U11687) unknown [Bacillus subtilis] >gi|1146214|gb|AAC83961.1| (L47648) cytidine monophosphate kinase [Bacillus subtilis] >gi|2634707|emb|CAB14205.1| (Z99115) cytidylate kinase [Bacillus subtilis] >gi|2634724|emb|CAB14221.1| (Z99116) cytidylate kinase [Bacillus subtilis]. | 0.901 |
comEB | cysD | SMU_1849 | SMU_1173 | Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. | Best Blastp Hit: dbj|BAB06322.1| (AP001516) O-acetylhomoserine sulfhydrylase [Bacillus halodurans]. | 0.507 |
comEB | kitH | SMU_1849 | SMU_1086 | Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. | Putative thymidine kinase; Best Blastp Hit: sp|P47848|KITH_STRGC THYMIDINE KINASE >gi|703442|gb|AAB02289.1| (L40415) thymidine kinase [Streptococcus gordonii]. | 0.937 |
comEB | kthY | SMU_1849 | SMU_1663 | Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. | Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.941 |
comEB | pepP | SMU_1849 | SMU_1850 | Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. | Putative aminopeptidase P; Best Blastp Hit: emb|CAA70068.1| (Y08842) aminopeptidase P [Lactococcus lactis]; Belongs to the peptidase M24B family. | 0.896 |
comEB | pyrG | SMU_1849 | SMU_97 | Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. | CTP synthetase (UTP-ammonia lyase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.626 |
comEB | thyA | SMU_1849 | SMU_944 | Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.939 |
comEB | uvrA | SMU_1849 | SMU_1851 | Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. | Putative excinuclease ABC (subunit A); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.723 |
cysD | comEB | SMU_1173 | SMU_1849 | Best Blastp Hit: dbj|BAB06322.1| (AP001516) O-acetylhomoserine sulfhydrylase [Bacillus halodurans]. | Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. | 0.507 |
kitH | SMU_325 | SMU_1086 | SMU_325 | Putative thymidine kinase; Best Blastp Hit: sp|P47848|KITH_STRGC THYMIDINE KINASE >gi|703442|gb|AAB02289.1| (L40415) thymidine kinase [Streptococcus gordonii]. | Putative dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.958 |