STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pflPyruvate formate-lyase; Best Blastp Hit: sp|Q59934|PFL_STRMU FORMATE ACETYLTRANSFERASE (PYRUVATE FORMATE-LYASE) >gi|1129082|dbj|BAA09085.1| (D50491) Pyruvate formate-lyase [Streptococcus mutans]. (775 aa)    
Predicted Functional Partners:
adhE
Best Blastp Hit: emb|CAA04467.1| (AJ001008) Alcohol-acetaldehyde dehydrogenase [Lactococcus lactis]; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
 
 
 0.987
ldh
Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
   
 
 0.979
pflA
Pyruvate-formate lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family.
 
  
 0.961
adhB
Putative acetoin dehydrogenase (TPP-dependent), E1 component beta subunit; Best Blastp Hit: dbj|BAB04496.1| (AP001509) acetoin dehydrogenase (TPP-dependent) beta chain [Bacillus halodurans].
   
 
 0.951
SMU_1043c
Putative phosphotransacetylase; Best Blastp Hit: sp|P39646|PTA_BACSU PROBABLE PHOSPHATE ACETYLTRANSFERASE (PHOSPHOTRANSACETYLASE) (VEGETATIVE PROTEIN 43) (VEG43) >gi|2126977|pir||S39743 phosphotransacetylase pta - Bacillus subtilis >gi|580883|emb|CAA51644.1| (X73124) ipa-88d [Bacillus subtilis] >gi|2636302|emb|CAB15793.1| (Z99123) phosphotransacetylase [Bacillus subtilis].
   
 
 0.945
adhD
Best Blastp Hit: pir||I40794 dihydrolipoamide dehydrogenase (EC 1.8.1.4) - Clostridium magnum >gi|472330|gb|AAA21748.1| (L31844) dihydrolipoamide dehydrogenase [Clostridium magnum].
   
 
 0.937
alsS
Alpha-acetolactate synthase; Best Blastp Hit: gb|AAA25161.1| (L16975) alpha-acetolactate synthase [Lactococcus lactis]; Belongs to the TPP enzyme family.
   
 
 0.936
pfl2
Best Blastp Hit: sp|P75793|PFLF_ECOLI PUTATIVE FORMATE ACETYLTRANSFERASE 3 (PYRUVATE FORMATE-LYASE 3) >gi|7427871|pir||G64819 probable formate C-acetyltransferase (EC 2.3.1.54) - Escherichia coli >gi|1787044|gb|AAC73910.1| (AE000184) putative formate acetyltransferase [Escherichia coli] >gi|4062397|dbj|BAA35511.1| (D90720) Formate acetyltransferase 2 (EC 2.3.1.54) (pyruvate formate-lyase 2). [Escherichia coli].
  
 
0.931
pycB
Putative pyruvate carboxylase/oxaloacetate decarboxylase, alpha subunit; Best Blastp Hit: sp|Q58628|PYCB_METJA PYRUVATE CARBOXYLASE SUBUNIT B (PYRUVIC CARBOXYLASE B) >gi|2129173|pir||F64453 oxaloacetate decarboxylase (EC 4.1.1.3) alpha chain MJ1231 [similarity] - Methanococcus jannaschii >gi|1591862|gb|AAB99233.1| (U67563) oxaloacetate decarboxylase alpha chain (oadA) [Methanococcus jannaschii].
   
 
 0.930
oadB
Putative oxaloacetate decarboxylase, sodium ion pump subunit; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD).
   
 
 0.928
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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