STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
luxSPutative autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (160 aa)    
Predicted Functional Partners:
pfs
Putative MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
 
 
 0.994
metB
Putative cystathionine gamma-synthase; Best Blastp Hit: pir||G64047 cystathionine gamma-lyase homolog - Haemophilus influenzae (strain Rd KW20) >gi|1573037|gb|AAC21764.1| (U32694) cystathionine gamma-synthase (metB) [Haemophilus influenzae Rd] 4.4.1.1 cystathionine gamma-lyase or cystathionine beta-lyases 4.4.8.1.
  
 
 0.967
metE
Putative homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.948
SMU_874
Conserved hypothetical protein; Best Blastp Hit: dbj|BAB05348.1| (AP001512) unknown conserved protein [Bacillus halodurans].
    
 0.942
SMU_952
Putative methyltransferase; Best Blastp Hit: pir||B69751 conserved hypothetical protein ybgG - Bacillus subtilis >gi|2632527|emb|CAB12035.1| (Z99105) similar to hypothetical proteins [Bacillus subtilis] >gi|3599664|dbj|BAA33139.1| (AB006424) ybgG [Bacillus subtilis].
  
  
 0.927
cysK
Putative cysteine synthetase A; Best Blastp Hit: dbj|BAA88310.1| (AB028865) O-acetylserine lyase [Streptococcus suis]; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.914
cysD
Best Blastp Hit: dbj|BAB06322.1| (AP001516) O-acetylhomoserine sulfhydrylase [Bacillus halodurans].
   
 
 0.906
metC
Best Blastp Hit: sp|Q08432|PATB_BACSU PUTATIVE AMINOTRANSFERASE B >gi|421526|pir||S32934 aminotransferase patB - Bacillus subtilis >gi|1934779|emb|CAB07910.1| (Z93933) aminotransferase [Bacillus subtilis] >gi|1934787|emb|CAB07924.1| (Z93934) aminotransferase [Bacillus subtilis] >gi|2231218|gb|AAB61979.1| (U63302) PatB [Bacillus subtilis] >gi|2635640|emb|CAB15133.1| (Z99120) aminotransferase [Bacillus subtilis].
   
 
  0.906
SMU_965
Best Blastp Hit: sp|P52985|DHOM_LACLA HOMOSERINE DEHYDROGENASE (HDH) >gi|2117450|pir||JC6049 homoserine dehydrogenase (EC 1.1.1.3) - Lactococcus lactis >gi|1255939|emb|CAA65713.1| (X96988) hom [Lactococcus lactis].
     
 0.814
gtfB
glucosyltransferase-I; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris; Belongs to the glycosyl hydrolase 70 family.
   
  
 0.808
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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