STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMU_506Putative type II restriction endonuclease; Recognizes the double-stranded unmethylated sequence GATC and cleaves before G-1; Belongs to the type II restriction enzyme DpnII family. (312 aa)    
Predicted Functional Partners:
SMU_505
Putative adenine-specific DNA methylase; Best Blastp Hit: sp|P09358|MT22_STRPN MODIFICATION METHYLASE DPNII 2 (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 2) (M.DPNII 2) >gi|6978344|gb|AAA88581.2| (M14339) DNA adenine methyltransferase [Streptococcus pneumoniae]; Belongs to the N(4)/N(6)-methyltransferase family.
 
  
 0.985
dam
Putative site-specific DNA-methyltransferase; Best Blastp Hit: sp|P50179|ML21_LACLC MODIFICATION METHYLASE LLADCHI A (ADENINE-SPECIFIC METHYLTRANSFERASE LLADCHI A) (M.LLADCHI A) (LLAII) >gi|794256|gb|AAB06311.1| (U16027) modification methylase LlaDCHIA [Lactococcus lactis].
 
    0.965
hup
Putative DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. Seems also to act as a fortuitous virulence factor in delayed sequelae by binding to heparan sulfate-proteoglycans in the extracellular matrix of target organs and acting as a nidus for in situ immune complex formation.
      
 0.625
ruvA
Putative Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
   
  
 0.621
metB
Putative cystathionine gamma-synthase; Best Blastp Hit: pir||G64047 cystathionine gamma-lyase homolog - Haemophilus influenzae (strain Rd KW20) >gi|1573037|gb|AAC21764.1| (U32694) cystathionine gamma-synthase (metB) [Haemophilus influenzae Rd] 4.4.1.1 cystathionine gamma-lyase or cystathionine beta-lyases 4.4.8.1.
      
 0.544
SMU_1309c
Best Blastp Hit: pir||T37628 glycerol dehydrogenase - fission yeast (Schizosaccharomyces pombe) >gi|2398802|emb|CAB11766.1| (Z99091) glycerol dehydrogenase [Schizosaccharomyces pombe].
   
  
 0.453
SMU_503c
Hypothetical protein.
       0.436
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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