node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alr | ddl | SMU_1834 | SMU_599 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Putative D-alanine-D-alanine ligase; Cell wall formation. | 0.980 |
alr | dltA | SMU_1834 | SMU_1691 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Putative D-alanine-D-alanyl carrier protein ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs t [...] | 0.908 |
alr | dltC | SMU_1834 | SMU_1689 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Putative D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.902 |
alr | murC | SMU_1834 | SMU_1731 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Putative UDP-N-acetyl muramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.682 |
alr | murD | SMU_1834 | SMU_548 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Putative D-glutamic acid adding enzyme MurD; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.705 |
alr | murE | SMU_1834 | SMU_1677 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Putative UDP-N-acetylmuramoylananine-D-glutamate-2,6- diaminopimelate ligase; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. | 0.463 |
alr | murF | SMU_1834 | SMU_603 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Putative D-Ala-D-Ala adding enzyme; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.963 |
alr | murG | SMU_1834 | SMU_549 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Putative MurG; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.520 |
alr | pbp2b | SMU_1834 | SMU_597 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Penicillin-binding protein 2b; Best Blastp Hit: gb|AAC44614.1| (U58210) penicillin-binding protein 2b [Streptococcus thermophilus]. | 0.428 |
ddl | alr | SMU_599 | SMU_1834 | Putative D-alanine-D-alanine ligase; Cell wall formation. | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.980 |
ddl | dltA | SMU_599 | SMU_1691 | Putative D-alanine-D-alanine ligase; Cell wall formation. | Putative D-alanine-D-alanyl carrier protein ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs t [...] | 0.918 |
ddl | dltC | SMU_599 | SMU_1689 | Putative D-alanine-D-alanine ligase; Cell wall formation. | Putative D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.911 |
ddl | murB | SMU_599 | SMU_972 | Putative D-alanine-D-alanine ligase; Cell wall formation. | Putative UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.976 |
ddl | murC | SMU_599 | SMU_1731 | Putative D-alanine-D-alanine ligase; Cell wall formation. | Putative UDP-N-acetyl muramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.983 |
ddl | murD | SMU_599 | SMU_548 | Putative D-alanine-D-alanine ligase; Cell wall formation. | Putative D-glutamic acid adding enzyme MurD; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.861 |
ddl | murE | SMU_599 | SMU_1677 | Putative D-alanine-D-alanine ligase; Cell wall formation. | Putative UDP-N-acetylmuramoylananine-D-glutamate-2,6- diaminopimelate ligase; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. | 0.841 |
ddl | murF | SMU_599 | SMU_603 | Putative D-alanine-D-alanine ligase; Cell wall formation. | Putative D-Ala-D-Ala adding enzyme; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.995 |
ddl | murG | SMU_599 | SMU_549 | Putative D-alanine-D-alanine ligase; Cell wall formation. | Putative MurG; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.871 |
ddl | pbp2b | SMU_599 | SMU_597 | Putative D-alanine-D-alanine ligase; Cell wall formation. | Penicillin-binding protein 2b; Best Blastp Hit: gb|AAC44614.1| (U58210) penicillin-binding protein 2b [Streptococcus thermophilus]. | 0.815 |
dltA | alr | SMU_1691 | SMU_1834 | Putative D-alanine-D-alanyl carrier protein ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs t [...] | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.908 |