STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
citBAconitate hydratase; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis- aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein. (888 aa)    
Predicted Functional Partners:
citZ
Citrate synthase; Best Blastp Hit: sp|Q59939|CISZ_STRMU CITRATE SYNTHASE >gi|1421813|gb|AAC44825.1| (U62799) citrate synthase [Streptococcus mutans].
 
 0.999
idh
Best Blastp Hit: sp|Q59940|IDH_STRMU ISOCITRATE DEHYDROGENASE [NADP] (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) >gi|1421814|gb|AAC44826.1| (U62799) isocitrate dehydrogenase [Streptococcus mutans].
  
 0.999
fabM
Putative enoyl-CoA hydratase; Catalyzes the isomerization of trans-2-decenoyl-ACP to cis-3- decenoyl-ACP (By similarity). Required for survival at low pH.
   
 
 0.791
sod
Putative manganese-type superoxide dismutase, Fe/Mn-SOD; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
   
 
 0.781
SMU_1657c
Putative nitrogen regulatory protein PII; Best Blastp Hit: emb|CAB94814.1| (AJ245582) hypothetical protein [Streptococcus thermophilus].
  
  
 0.770
nrgA
Putative ammonium transporter, NrgA protein; Best Blastp Hit: gb|AAF73971.1| (U81166) NrgA-like protein [Lactococcus lactis subsp. cremoris].
  
 
 0.756
rl19
50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
   
 
 0.749
rl5
50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
   
 
 0.721
rpmB
50S ribosomal protein L28; Best Blastp Hit: dbj|BAB06219.1| (AP001515) ribosomal protein L28 [Bacillus halodurans]; Belongs to the bacterial ribosomal protein bL28 family.
   
   0.720
rpmJ
50S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.
   
 
 0.710
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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