STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ptsIPhosphoenolpyruvate:sugar phosphotransferase system enzyme I, PTS system EI component; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (577 aa)    
Predicted Functional Partners:
ptsH
Phosphoenolpyruvate:sugar phosphotransferase system HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
 
 0.999
ptsG
Putative PTS system, glucose-specific IIABC component; Best Blastp Hit: gb|AAD00281.1| (U78600) putative ptsG## protein [Streptococcus mutans].
 
 0.979
bglP
Putative PTS system, beta-glucoside-specific EII component; Best Blastp Hit: gb|AAF89975.1|AF206272_1 (AF206272) beta-glucoside-specific EII permease [Streptococcus mutans].
 
 0.949
pttB
Best Blastp Hit: pir||B82263 PTS system, trehalose-specific IIBC component VC0910 [imported] - Vibrio cholerae (group O1 strain N16961) >gi|9655367|gb|AAF94072.1| (AE004175) PTS system, trehalose-specific IIBC component [Vibrio cholerae].
 
 0.943
fruI
Best Blastp Hit: dbj|BAB04547.1| (AP001510) PTS system, fructose-specific enzyme II, BC component [Bacillus halodurans].
 
  
 0.930
scrA
Putative PTS system, sucrose-specific IIABC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in sucrose transport.
 
 0.906
fruC
Best Blastp Hit: dbj|BAB04547.1| (AP001510) PTS system, fructose-specific enzyme II, BC component [Bacillus halodurans].
 
  
 0.887
mtlA2
PTS system, mannitol-specific enzyme IIA; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.
     
 0.758
fruD
Best Blastp Hit: pir||H69626 PTS fructose-specific enzyme IIBC component fruA - Bacillus subtilis >gi|2633811|emb|CAB13313.1| (Z99111) phosphotransferase system (PTS) fructose-specific enzyme IIBC component [Bacillus subtilis] >gi|3282125|gb|AAC24915.1| (AF012285) fructose PTS IIABC [Bacillus subtilis].
 
  
 0.688
SMU_1960c
Putative PTS system, mannose-specific IIB component; Best Blastp Hit: gb|AAB04152.1| (U28163) phosphoenolpyruvate:mannose phosphotransferase element IIB [Lactobacillus curvatus].
  
  
 0.662
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.