STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMU_776Conserved hypothetical protein; Best Blastp Hit: sp|P39587|YWBD_BACSU HYPOTHETICAL 44.4 KD PROTEIN IN EPR-GALK INTERGENIC REGION >gi|629026|pir||S39674 ywbD protein - Bacillus subtilis >gi|413943|emb|CAA51575.1| (X73124) ipa-19d [Bacillus subtilis] >gi|2636371|emb|CAB15862.1| (Z99123) alternate gene name: ipa-19d similar to hypothetical proteins [Bacillus subtilis]. (385 aa)    
Predicted Functional Partners:
SMU_472
Conserved hypothetical protein; Best Blastp Hit: sp|P50840|YPSC_BACSU HYPOTHETICAL 43.5 KD PROTEIN IN COTD-KDUD INTERGENIC REGION PRECURSOR >gi|7459586|pir||F69941 conserved hypothetical protein ypsC - Bacillus subtilis >gi|1146183|gb|AAB38473.1| (L47838) putative [Bacillus subtilis] >gi|2634636|emb|CAB14134.1| (Z99115) similar to hypothetical proteins [Bacillus subtilis]; Belongs to the methyltransferase superfamily.
 
  
 0.990
SMU_788
Putative RNA methyltransferase; Best Blastp Hit: dbj|BAB04406.1| (AP001509) RNA methyltransferase [Bacillus halodurans]; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
  
  
 0.918
SMU_1779c
Best Blastp Hit: pir||F69806 RNA methyltransferase homolog yfjO - Bacillus subtilis >gi|2633126|emb|CAB12631.1| (Z99108) similar## to RNA methyltransferase [Bacillus subtilis] >gi|2780399|dbj|BAA24300.1| (D78509) YfjO [Bacillus subtilis]; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
  
  
 0.899
aroD
Putative 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family.
       0.800
aroE
Putative shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
       0.800
aroB
Putative 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
       0.772
aroC
Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
       0.772
SMU_781
Best Blastp Hit: sp|P43901|TYRA_LACLA PREPHENATE DEHYDROGENASE (PDH) >gi|1075739|pir||S52579 prephenate dehydrogenase (EC 1.3.1.12) - Lactococcus lactis >gi|683582|emb|CAA55179.1| (X78413) prephenate dehydrogenase [Lactococcus lactis].
       0.615
SMU_782
Best Blastp Hit: pir||A69828 hypothetical protein yheA - Bacillus subtilis >gi|2226157|emb|CAA74444.1| (Y14080) hypothetical protein [Bacillus subtilis] >gi|2633315|emb|CAB12819.1| (Z99109) yheA [Bacillus subtilis]; Belongs to the UPF0342 family.
     
 0.609
rsmA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
      
 0.600
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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