STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gtfASucrose phosphorylase, GtfA; Intracellular catabolism of sucrose. Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris. (481 aa)    
Predicted Functional Partners:
msmE
Multiple sugar-binding ABC transporter, sugar-binding protein precursor MsmE; Involved in a binding protein-dependent transport system responsible for the uptake of melibiose, raffinose and isomaltotriose.
 
  
 0.985
msmK
Multiple sugar-binding ABC transporter, ATP-binding protein, MsmK; Involved in a binding protein-dependent transport system responsible for the uptake of melibiose, raffinose and isomaltotriose. Probably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily.
  
  
 0.982
dexB
Dextran glucosidase DexB; The physiological substrates may be short isomaltosaccharides.
  
  
 0.981
scrB
Best Blastp Hit: sp|P13522|SCRB_STRMU SUCROSE-6-PHOSPHATE## HYDROLASE (SUCRASE) (INVERTASE) >gi|97999|pir||A43501 sucrose-6-phosphate hydrolase - Streptococcus mutans >gi|47259|emb|CAA35872.1| (X51507) sucrose-6-phosphate hydrolase [Streptococcus mutans] >gi|153804|gb|AAA26972.1| (M36849) sucrose-6-phosphate hydrolase [Streptococcus mutans].
  
 
 0.977
msmG
Multiple sugar-binding ABC transporter, permease protein MsmG; Involved in a binding protein-dependent transport system responsible for the uptake of melibiose, raffinose and isomaltotriose; Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
 
  
 0.977
msmF
Multiple sugar-binding ABC transporter, permease protein MsmF; Involved in a binding protein-dependent transport system responsible for the uptake of melibiose, raffinose and isomaltotriose; Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
 
  
 0.975
gtfB
glucosyltransferase-I; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris; Belongs to the glycosyl hydrolase 70 family.
   
 
 0.973
agaL
Alpha-galactosidase; Best Blastp Hit: sp|P27756|AGAL_STRMU ALPHA-GALACTOSIDASE (MELIBIASE) >gi|322116|pir||A44819 alpha-galactosidase (EC 3.2.1.22) - Streptococcus mutans >gi|153736|gb|AAA26933.1| (M77351) a-galactosidase [Streptococcus mutans]; Belongs to the glycosyl hydrolase 36 family.
 
  
 0.973
sacB
Levansucrase precursor; Best Blastp Hit: sp|P11701|SACB_STRMU LEVANSUCRASE## PRECURSOR (BETA-D-FRUCTOFURANOSYL TRANSFERASE) (SUCROSE 6-FRUCTOSYL TRANSFERASE) >gi|79999|pir||B28551 levansucrase (EC 2.4.1.10) precursor - Streptococcus mutans (strain GS-5) >gi|153636|gb|AAA88584.1| (M18954) fructosyltransferase [Streptococcus mutans]; Belongs to the glycosyl hydrolase 68 family.
  
 
 0.971
gtfC
glucosyltransferase-SI; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris; Belongs to the glycosyl hydrolase 70 family.
   
 
 0.961
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.