STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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[Homology]
Score
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (279 aa)    
Predicted Functional Partners:
dfrA
Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
 
 
 0.997
SMU_325
Putative dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  
 0.960
kitH
Putative thymidine kinase; Best Blastp Hit: sp|P47848|KITH_STRGC THYMIDINE KINASE >gi|703442|gb|AAB02289.1| (L40415) thymidine kinase [Streptococcus gordonii].
  
 
 0.959
comEB
Putative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans].
  
 
 0.939
kthY
Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.938
folD
Putative tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.938
glyA
Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.934
SMU_874
Conserved hypothetical protein; Best Blastp Hit: dbj|BAB05348.1| (AP001512) unknown conserved protein [Bacillus halodurans].
  
 
 0.934
folC
Putative folyl-polyglutamate synthetase; Best Blastp Hit: sp|Q05865|FOLC_BACSU FOLYLPOLYGLUTAMATE SYNTHASE (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) >gi|421496|pir||B40646 folyl-polyglutamate synthetase folC - Bacillus subtilis >gi|142936|gb|AAB59021.1| (L04520) folyl-polyglutamate synthetase [Bacillus subtilis] >gi|2635273|emb|CAB14768.1| (Z99118) folyl-polyglutamate synthetase [Bacillus subtilis].
   
 
 0.824
fol
Putative folyl-polyglutamate synthetase; Best Blastp Hit: sp|Q05865|FOLC_BACSU FOLYLPOLYGLUTAMATE SYNTHASE (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) >gi|421496|pir||B40646 folyl-polyglutamate synthetase folC - Bacillus subtilis >gi|142936|gb|AAB59021.1| (L04520) folyl-polyglutamate synthetase [Bacillus subtilis] >gi|2635273|emb|CAB14768.1| (Z99118) folyl-polyglutamate synthetase [Bacillus subtilis].
   
 
 0.822
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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