STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folEBest Blastp Hit: sp|O33723|GCH1_STRPY GTP CYCLOHYDROLASE I (GTP-CH-I) >gi|3242315|emb|CAA04237.1| (AJ000685) GTP cyclohydrolase [Streptococcus pyogenes]. (192 aa)    
Predicted Functional Partners:
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
 0.998
folK
Putative 2-amino-4-hydroxy-6-hydroxymethylpteridine pyrophosphokinase; Best Blastp Hit: dbj|BAB03814.1| (AP001507) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [Bacillus halodurans].
  
 0.998
SMU_917c
Putative 6-pyruvoyl tetrahydropterin synthase; Best Blastp Hit: pir||C72425 hypothetical protein TM0038 - Thermotoga maritima (strain MSB8) >gi|4980523|gb|AAD35132.1|AE001691_6 (AE001691) 6-pyruvoyl tetrahydrobiopterin synthase, putative [Thermotoga maritima].
  
 
 0.988
folA
Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
  
 0.986
folC
Putative folyl-polyglutamate synthetase; Best Blastp Hit: sp|Q05865|FOLC_BACSU FOLYLPOLYGLUTAMATE SYNTHASE (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) >gi|421496|pir||B40646 folyl-polyglutamate synthetase folC - Bacillus subtilis >gi|142936|gb|AAB59021.1| (L04520) folyl-polyglutamate synthetase [Bacillus subtilis] >gi|2635273|emb|CAB14768.1| (Z99118) folyl-polyglutamate synthetase [Bacillus subtilis].
  
  
 0.971
asd
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
  
  
 0.830
pykF
Pyruvate kinase; Best Blastp Hit: gb|AAF25804.1|AF172173_2 (AF172173) pyruvate kinase [Streptococcus thermophilus].
  
 
  0.807
relA
Putative stringent response protein, ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
   
 
  0.803
SMU_1046c
Putative GTP pyrophosphokinase; Best Blastp Hit: dbj|BAB06568.1| (AP001516) GTP pyrophosphokinase [Bacillus halodurans].
   
 
  0.800
nrdD
Best Blastp Hit: gb|AAD00215.1| (U73336) anaerobic ribonucleotide reductase [Lactococcus lactis subsp. cremoris].
     
  0.800
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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